Campylobacter Pylori in the Upper Gastrointestinal Tract of Patients with HIV-1 Infection

Overview

Journal J Clin Pathol

Specialty Pathology

Date 1990 Jan 1

PMID 2312753

Citations 7

Authors

N D Francis

R P Logan

M M Walker

R J Polson

A W Boylston

A J Pinching

J R Harris

J H Baron

Affiliations

Soon will be listed here.

Abstract

Fifty one patients with human immuno-deficiency virus (HIV-1) infection who had been consecutively endoscoped for upper gastrointestinal symptoms were biopsied (stomach or duodenum, or both) and compared with 59 age and sex matched controls for the presence of Campylobacter pylori. In 28 (47%) of the control group but in only seven (14%) of the HIV seropositive patients were C pylori seen on histological examination (p less than 0.001, odds ratio 5.6, 95% confidence interval 2.2-14.5). Sixteen patients who were HIV antibody positive had other index diseases for the diagnosis of AIDS in the biopsy material and, when these were excluded, comparison with the control group still showed a significant difference; p less than 0.01, odds ratio 3.6, 95%, confidence interval 1.4-9.6. In this series, therefore, C pylori were far less common in HIV antibody positive patients than in controls. Among the HIV positive patients, a higher proportion of C pylori negative cases had AIDS but this trend was not significant. The findings of this study indicate that whatever abnormalities of cell mediated mucosal immunoregulation are caused by HIV infection, they do not seem to be important in the response to infection by C pylori.

Citing Articles

Seroprevalence of helicobacter pylori in human immunodeficiency virus-positive Patients and it's correlation with CD4(+) Lymphocyte Count.

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Retracted: Increased risk of stomach and esophageal malignancies in people with AIDS.

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Low prevalence of H. pylori infection in HIV-positive patients in the northeast of Brazil.

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A low prevalence of H pylori and endoscopic findings in HIV-positive Chinese patients with gastrointestinal symptoms.

Lv F, Luo X, Meng X, Jin R, Ding H, Zhang S World J Gastroenterol. 2007; 13(41):5492-6.

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Audit of endoscopic surveillance biopsy specimens in HIV positive patients with gastrointestinal symptoms.

Lim S, Lipman M, Squire S, Pillay D, Gillespie S, Sankey E Gut. 1993; 34(10):1429-32.

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References

Warren J, Marshall B . Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet. 1983; 1(8336):1273-5. View

Quinn T, Goodell S, Fennell C, Wang S, Schuffler M, Holmes K . Infections with Campylobacter jejuni and Campylobacter-like organisms in homosexual men. Ann Intern Med. 1984; 101(2):187-92. DOI: 10.7326/0003-4819-101-2-187. View

Marshall B, McGechie D, Rogers P, Glancy R . Pyloric Campylobacter infection and gastroduodenal disease. Med J Aust. 1985; 142(8):439-44. DOI: 10.5694/j.1326-5377.1985.tb113444.x. View

Rathbone B, Wyatt J, Worsley B, Trejdosiewicz L, Heatley R, Losowsky M . Immune response to Campylobacter pyloridis. Lancet. 1985; 1(8439):1217. DOI: 10.1016/s0140-6736(85)92897-1. View

Rathbone B, Wyatt J, Worsley B, Shires S, Trejdosiewicz L, Heatley R . Systemic and local antibody responses to gastric Campylobacter pyloridis in non-ulcer dyspepsia. Gut. 1986; 27(6):642-7. PMC: 1433340. DOI: 10.1136/gut.27.6.642. View

McNulty C, Gearty J, Crump B, Davis M, Donovan I, Melikian V . Campylobacter pyloridis and associated gastritis: investigator blind, placebo controlled trial of bismuth salicylate and erythromycin ethylsuccinate. Br Med J (Clin Res Ed). 1986; 293(6548):645-9. PMC: 1341508. DOI: 10.1136/bmj.293.6548.645. View

Ellakany S, Whiteside T, Schade R, Van Thiel D . Analysis of intestinal lymphocyte subpopulations in patients with acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. Am J Clin Pathol. 1987; 87(3):356-64. DOI: 10.1093/ajcp/87.3.356. View

Borromeo M, Lambert J, Pinkard K . Evaluation of "CLO-test" to detect Campylobacter pyloridis in gastric mucosa. J Clin Pathol. 1987; 40(4):462-3. PMC: 1140984. DOI: 10.1136/jcp.40.4.462. View

Whittingham S, Naselli G, McNeilage L, Coppel R, Sturgess A . Serological diagnosis of primary Sjögren's syndrome by means of human recombinant La (SS-B) as nuclear antigen. Lancet. 1987; 2(8549):1-3. View

10.

Aceti A, Attanasio R, Pennica A, Taliani G, Sebastiani A, Rezza G . Campylobacter pylori infection in homosexuals. Lancet. 1987; 2(8551):154-5. DOI: 10.1016/s0140-6736(87)92351-8. View

11.

Meiselman M, Christ M, Randall E . Campylobacter pylori gastritis in the acquired immunodeficiency syndrome. Gastroenterology. 1988; 95(1):209-12. DOI: 10.1016/0016-5085(88)90314-9. View

12.

Marshall B, Goodwin C, Warren J, Murray R, Blincow E, Blackbourn S . Prospective double-blind trial of duodenal ulcer relapse after eradication of Campylobacter pylori. Lancet. 1988; 2(8626-8627):1437-42. DOI: 10.1016/s0140-6736(88)90929-4. View

13.

Goodwin C . Duodenal ulcer, Campylobacter pylori, and the "leaking roof" concept. Lancet. 1988; 2(8626-8627):1467-9. DOI: 10.1016/s0140-6736(88)90942-7. View

14.

Griffin G, Miller A, Batman P, Forster S, Pinching A, Harris J . Damage to jejunal intrinsic autonomic nerves in HIV infection. AIDS. 1988; 2(5):379-82. DOI: 10.1097/00002030-198810000-00008. View

15.

Miller A, Griffin G, Batman P, Farquar C, Forster S, Pinching A . Jejunal mucosal architecture and fat absorption in male homosexuals infected with human immunodeficiency virus. Q J Med. 1988; 69(260):1009-19. View