Low Prevalence of H. Pylori Infection in HIV-positive Patients in the Northeast of Brazil

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Specialty Gastroenterology

Date 2011 Feb 22

PMID 21333017

Citations 12

Authors

Andrea B C Fialho

Manuel B Braga-Neto

Eder J C Guerra

Andre M N Fialho

Karine C Fernandes

Juliana L M Sun

Christianne F V Takeda

Cicero I S Silva

Dulciene M M Queiroz

Lucia L B C Braga

Affiliations

Soon will be listed here.

Abstract

Background: This study conducted in Northeastern Brazil, evaluated the prevalence of H. pylori infection and the presence of gastritis in HIV-infected patients.

Methods: There were included 113 HIV-positive and 141 age-matched HIV-negative patients, who underwent upper gastrointestinal endoscopy for dyspeptic symptoms. H. pylori status was evaluated by urease test and histology.

Results: The prevalence of H. pylori infection was significantly lower (p < 0.001) in HIV-infected (37.2%) than in uninfected (75.2%) patients. There were no significant differences between H. pylori status and gender, age, HIV viral load, antiretroviral therapy and the use of antibiotics. A lower prevalence of H. pylori was observed among patients with T CD4 cell count below 200/mm3; however, it was not significant. Chronic active antral gastritis was observed in 87.6% of the HIV-infected patients and in 780.4% of the control group (p = 0.11). H. pylori infection was significantly associated with chronic active gastritis in the antrum in both groups, but it was not associated with corpus chronic active gastritis in the HIV-infected patients.

Conclusion: We demonstrated that the prevalence of H. pylori was significantly lower in HIV-positive patients compared with HIV-negative ones. However, corpus gastritis was frequently observed in the HIV-positive patients, pointing to different mechanisms than H. pylori infection in the genesis of the lesion.

Citing Articles

CD4 T cell count and HIV-1 viral load dynamics positively impacted by H. pylori infection in HIV-positive patients regardless of ART status in a high-burden setting.

Abadi T, Teklu T, Wondmagegn T, Alem M, Desalegn G Eur J Med Res. 2024; 29(1):178.

PMID: 38494500 PMC: 10946129. DOI: 10.1186/s40001-024-01750-6.

Nkuize M, De Wit S Microorganisms. 2022; 10(8).

PMID: 36013959 PMC: 9413132. DOI: 10.3390/microorganisms10081541.

Prevalence of among asymptomatic HIV-positive and negative individuals in Central Ethiopia and efficacy of eradication therapy.

Mesfun M, Gliga S, Fuchs A, Orth H, Schonfeld A, Luedde T IJID Reg. 2022; 2:169-174.

PMID: 35757079 PMC: 9216691. DOI: 10.1016/j.ijregi.2022.01.007.

Helicobacter pylori infection rates in dyspeptic Serbian HIV-infected patients compared to HIV-negative controls.

Radovanovic Spurnic A, Bukumiric Z, Jevtovic D, Brmbolic B, Pekmezovic T, Salemovic D PLoS One. 2021; 16(3):e0248041.

PMID: 33690620 PMC: 7946278. DOI: 10.1371/journal.pone.0248041.

Alterations of the gut bacterial microbiota in rhesus macaques with SIV infection and on short- or long-term antiretroviral therapy.

Siddiqui S, Bao D, Doyle-Meyers L, Dufour J, Wu Y, Liu Y Sci Rep. 2020; 10(1):19056.

PMID: 33149234 PMC: 7642356. DOI: 10.1038/s41598-020-76145-8.

References

Dooley C, Cohen H, Fitzgibbons P, Bauer M, APPLEMAN M, Perez-Perez G . Prevalence of Helicobacter pylori infection and histologic gastritis in asymptomatic persons. N Engl J Med. 1989; 321(23):1562-6. DOI: 10.1056/NEJM198912073212302. View

Lim S, Lipman M, Squire S, Pillay D, Gillespie S, Sankey E . Audit of endoscopic surveillance biopsy specimens in HIV positive patients with gastrointestinal symptoms. Gut. 1993; 34(10):1429-32. PMC: 1374556. DOI: 10.1136/gut.34.10.1429. View

Welage L, Carver P, Revankar S, Pierson C, Kauffman C . Alterations in gastric acidity in patients infected with human immunodeficiency virus. Clin Infect Dis. 1995; 21(6):1431-8. DOI: 10.1093/clinids/21.6.1431. View

Dieterich D, Wilcox C . Diagnosis and treatment of esophageal diseases associated with HIV infection. Practice Parameters Committee of the American College of Gastroenterology. Am J Gastroenterol. 1996; 91(11):2265-9. View

Mach T, Skwara P, Biesiada G, Ciesla A, Macura A . Morphological changes of the upper gastrointestinal tract mucosa and Helicobacter pylori infection in HIV-positive patients with severe immunodeficiency and symptoms of dyspepsia. Med Sci Monit. 2006; 13(1):CR14-9. View

PETERSON W . Helicobacter pylori and peptic ulcer disease. N Engl J Med. 1991; 324(15):1043-8. DOI: 10.1056/NEJM199104113241507. View

Werneck-Silva A, Prado I . Dyspepsia in HIV-infected patients under highly active antiretroviral therapy. J Gastroenterol Hepatol. 2007; 22(11):1712-6. DOI: 10.1111/j.1440-1746.2007.04897.x. View

Romanelli F, Smith K, Murphy B . Does HIV infection alter the incidence or pathology of Helicobacter pylori infection?. AIDS Patient Care STDS. 2007; 21(12):908-19. DOI: 10.1089/apc.2006.0215. View

Moran A, Svennerholm A, Penn C . Pathogenesis and host response of Helicobacter pylori. Trends Microbiol. 2003; 10(12):545-7. DOI: 10.1016/s0966-842x(02)02481-2. View

10.

Rodrigues M, Queiroz D, Rodrigues R, Rocha A, Braga Neto M, Braga L . Helicobacter pylori infection in adults from a poor urban community in northeastern Brazil: demographic, lifestyle and environmental factors. Braz J Infect Dis. 2006; 9(5):405-10. DOI: 10.1590/s1413-86702005000500008. View

11.

Francis N, Logan R, Walker M, Polson R, Boylston A, Pinching A . Campylobacter pylori in the upper gastrointestinal tract of patients with HIV-1 infection. J Clin Pathol. 1990; 43(1):60-2. PMC: 502226. DOI: 10.1136/jcp.43.1.60. View

12.

Chiu H, Wu M, Hung C, Shun C, Lin J . Low prevalence of Helicobacter pylori but high prevalence of cytomegalovirus-associated peptic ulcer disease in AIDS patients: Comparative study of symptomatic subjects evaluated by endoscopy and CD4 counts. J Gastroenterol Hepatol. 2004; 19(4):423-8. DOI: 10.1111/j.1440-1746.2003.03278.x. View

13.

Bamford K, Fan X, Crowe S, Leary J, Gourley W, Luthra G . Lymphocytes in the human gastric mucosa during Helicobacter pylori have a T helper cell 1 phenotype. Gastroenterology. 1998; 114(3):482-92. DOI: 10.1016/s0016-5085(98)70531-1. View

14.

Edwards P, Carrick J, Turner J, Lee A, Mitchell H, Cooper D . Helicobacter pylori-associated gastritis is rare in AIDS: antibiotic effect or a consequence of immunodeficiency?. Am J Gastroenterol. 1991; 86(12):1761-4. View

15.

Lake-Bakaar G, Quadros E, Beidas S, Elsakr M, Tom W, Wilson D . Gastric secretory failure in patients with the acquired immunodeficiency syndrome (AIDS). Ann Intern Med. 1988; 109(6):502-4. DOI: 10.7326/0003-4819-109-6-502. View

16.

Lichterfeld M, Lorenz C, Nischalke H, Scheurlen C, Sauerbruch T, Rockstroh J . Decreased prevalence of Helicobacter pylori infection in HIV patients with AIDS defining diseases. Z Gastroenterol. 2002; 40(1):11-4. DOI: 10.1055/s-2002-19637. View

17.

Battan R, Raviglione M, Palagiano A, Boyle J, SABATINI M, Sayad K . Helicobacter pylori infection in patients with acquired immune deficiency syndrome. Am J Gastroenterol. 1990; 85(12):1576-9. View

18.

Bontems P, Robert F, Van Gossum A, Cadranel S, Mascart F . Helicobacter pylori modulation of gastric and duodenal mucosal T cell cytokine secretions in children compared with adults. Helicobacter. 2003; 8(3):216-26. DOI: 10.1046/j.1523-5378.2003.00147.x. View

19.

Olmos M, Araya V, Pskorz E, Quesada E, Concetti H, Perez H . Coinfection: Helicobacter pylori/human immunodeficiency virus. Dig Dis Sci. 2005; 49(11-12):1836-9. DOI: 10.1007/s10620-004-9580-5. View

20.

Shaffer R, LaHatte L, Kelly J, Kadakia S, Carrougher J, Keate R . Gastric acid secretion in HIV-1 infection. Am J Gastroenterol. 1992; 87(12):1777-80. View