Design and Discovery of New (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides As Potent Renin Inhibitors

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2012 Nov 6

PMID 23122821

Citations 3

Authors

Yutaka Mori

Yasuyuki Ogawa

Akiyoshi Mochizuki

Yuji Nakamura

Chie Sugita

Shojiro Miyazaki

Kazuhiko Tamaki

Yumi Matsui

Mizuki Takahashi

Takahiro Nagayama

Yoko Nagai

Shin-Ichi Inoue

Takahide Nishi

Affiliations

Soon will be listed here.

Abstract

Utilizing X-ray crystal structure analysis, (3S,5R)-5-[4-(2-chlorophenyl)-2,2-dimethyl-5-oxopiperazin-1-yl]piperidine-3-carboxamides were designed and identified as renin inhibitors. The most potent compound 15 demonstrated favorable pharmacokinetic and pharmacodynamic profiles in rat.

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