Systems Analysis of Plant Functional, Transcriptional, Physical Interaction, and Metabolic Networks

Overview

Journal Plant Cell

Publisher Oxford University Press

Specialties Biology
Cell Biology

Date 2012 Nov 1

PMID 23110892

Citations 47

Authors

George W Bassel

Allison Gaudinier

Siobhan M Brady

Lars Hennig

Seung Y Rhee

Ive De Smet

Affiliations

Soon will be listed here.

Abstract

Physiological responses, developmental programs, and cellular functions rely on complex networks of interactions at different levels and scales. Systems biology brings together high-throughput biochemical, genetic, and molecular approaches to generate omics data that can be analyzed and used in mathematical and computational models toward uncovering these networks on a global scale. Various approaches, including transcriptomics, proteomics, interactomics, and metabolomics, have been employed to obtain these data on the cellular, tissue, organ, and whole-plant level. We summarize progress on gene regulatory, cofunction, protein interaction, and metabolic networks. We also illustrate the main approaches that have been used to obtain these networks, with specific examples from Arabidopsis thaliana, and describe the pros and cons of each approach.

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