» Articles » PMID: 23101985

Liver Cancer and Alcohol

Overview
Journal Clin Liver Dis
Specialty Gastroenterology
Date 2012 Oct 30
PMID 23101985
Citations 47
Authors
Affiliations
Soon will be listed here.
Abstract

Annually, hepatocellular carcinoma is diagnosed in approximately a half-million people worldwide. Based on the association of alcohol with cancer, a International Agency for Research on Cancer working group recently deemed alcoholic beverages "carcinogenic to humans," causally related to occurrence of malignant tumors of the oral cavity, pharynx, larynx, esophagus, liver, colorectum, and female breast. Alcohol metabolism in the liver leads to reactive oxygen species production, induction of activity of cytochrome P450s, and reduction of antioxidants. This review analyzes the epidemiology and pathogenesis of alcohol in hepatocellular cancer.

Citing Articles

Sleep and liver function biomarkers in relation to risk of incident liver cancer: a nationwide prospective cohort study.

Song J, Fan L, Shi D, Lai X, Wang H, Liu W BMC Med. 2024; 22(1):261.

PMID: 38915009 PMC: 11197319. DOI: 10.1186/s12916-024-03440-w.


The role of alpha-fetoprotein in the tumor microenvironment of hepatocellular carcinoma.

Lu Y, Lin B, Li M Front Oncol. 2024; 14:1363695.

PMID: 38660138 PMC: 11039944. DOI: 10.3389/fonc.2024.1363695.


Protective Effect of Alpha-Linolenic Acid on Human Oral Squamous Cell Carcinoma Metastasis and Apoptotic Cell Death.

Su C, Yu C, Shih Y, Liu K, Chen H, Wu C Nutrients. 2023; 15(23).

PMID: 38068849 PMC: 10708481. DOI: 10.3390/nu15234992.


Circulating metabolites may illustrate relationship of alcohol consumption with cardiovascular disease.

Li Y, Wang M, Liu X, Rong J, Miller P, Joehanes R BMC Med. 2023; 21(1):443.

PMID: 37968697 PMC: 10652547. DOI: 10.1186/s12916-023-03149-2.


Dynamic changes of DNA methylation induced by benzo(a)pyrene in cancer.

Wang H, Liu B, Chen H, Xu P, Xue H, Yuan J Genes Environ. 2023; 45(1):21.

PMID: 37391844 PMC: 10314634. DOI: 10.1186/s41021-023-00278-1.