Dynamic Changes of DNA Methylation Induced by Benzo(a)pyrene in Cancer

Overview

Journal Genes Environ

Publisher Biomed Central

Specialty Environmental Health

Date 2023 Jun 30

PMID 37391844

Authors

Huizeng Wang

Bingchun Liu

Hong Chen

Peixin Xu

Huiting Xue

Jianlong Yuan

Affiliations

Soon will be listed here.

Abstract

Benzo(a)pyrene (BaP), the earliest and most significant carcinogen among polycyclic aromatic hydrocarbons (PAHs), has been found in foods, tobacco smoke, and automobiles exhaust, etc. Exposure to BaP induced DNA damage directly, or oxidative stress-related damage, resulting in cell apoptosis and carcinogenesis in human respiratory system, digestive system, reproductive system, etc. Moreover, BaP triggered genome-wide epigenetic alterations by methylation, which might cause disturbances in regulation of gene expression, and thereby induced cancer. It has been proved that BaP reduced genome-wide DNA methylation, and activated proto-oncogene by hypomethylation in the promoter region, but silenced tumor suppressor genes by promoter hypermethylation, resulting in cancer initiation and progression. Here we summarized the changes in DNA methylation in BaP exposure, and revealed the methylation of DNA plays a role in cancer development.

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