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When Secondary Comes First--the Importance of Non-canonical DNA Structures

Overview
Journal Biochimie
Specialty Biochemistry
Date 2012 Oct 23
PMID 23084930
Citations 27
Authors
Natalie Saini
Yu Zhang
Karen Usdin
Kirill S Lobachev
Affiliations
Soon will be listed here.
Abstract

Secondary structure-forming DNA motifs have achieved infamy because of their association with a variety of human diseases and cancer. The 3rd FASEB summer conference on dynamic DNA structures focused on the mechanisms responsible for the instabilities inherent to repetitive DNA and presented many exciting and novel aspects related to the metabolism of secondary structures. In addition, the meeting encompassed talks and posters on the dynamic structures that are generated during DNA metabolism including nicked DNA, Holliday junctions and RNA:DNA hybrids. New approaches for analysis and sequencing technologies put forth secondary structures and other DNA intermediates as vital regulators of a variety of cellular processes that contribute to evolution, polymorphisms and diseases.

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