Vitamin D in Cutaneous Carcinogenesis: Part I

Overview

Journal J Am Acad Dermatol

Specialty Dermatology

Date 2012 Oct 16

PMID 23062903

Citations 19

Authors

Jean Y Tang

Teresa Fu

Christopher Lau

Dennis H Oh

Daniel D Bikle

Maryam M Asgari

Affiliations

Soon will be listed here.

Abstract

Skin cancer is the most common cancer in the United States. Exposure to ultraviolet radiation is a known risk factor for skin cancer but is also the principal means by which the body obtains vitamin D. Several studies have suggested that vitamin D plays a protective role in a variety of internal malignancies. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar protective effect. These noncalcemic actions of vitamin D have called into question whether the current recommended intake of vitamin D is too low for optimal health and cancer prevention. Part I will review the role of vitamin D in the epidermis; part II will review the role of vitamin D in keratinocyte-derived tumors to help frame the discussion on the possible role of vitamin D in the prevention of skin cancer.

Citing Articles

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Significant Association of Poly-A and Fok1 Polymorphic Alleles of the Vitamin D Receptor with Vitamin D Serum Levels and Incidence of Squamous Cutaneous Neoplasia.

Bullock T, Mack J, Negrey J, Kaw U, Hu B, Anand S J Invest Dermatol. 2023; 143(8):1538-1547.

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Zhaoyong Z, Jieyi G, Pengwei W ScientificWorldJournal. 2022; 2022:8201972.

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Significant improvement of facial actinic keratoses after blue light photodynamic therapy with oral vitamin D pretreatment: An interventional cohort-controlled trial.

Bullock T, Negrey J, Hu B, Warren C, Hasan T, Maytin E J Am Acad Dermatol. 2022; 87(1):80-86.

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