The Anatomical and Physiological Framework for Vestibular Prostheses

Overview

Journal Anat Rec (Hoboken)

Specialty Anatomy & Histology

Date 2012 Oct 10

PMID 23044714

Citations 8

Authors

Stephen M Highstein

Gay R Holstein

Affiliations

Soon will be listed here.

Abstract

This article reviews the structure function of the vestibular system and its pathology with respect to requirements for the design and construction of a functional vestibular prosthesis. The ultimate goal of a vestibular prosthesis is to restore balance and equilibrium through direct activation of vestibular nerve fibers. An overview of the peripheral and central vestibular systems that highlights their most important functional aspects re: the design of a prosthesis is provided. Namely, the peripheral labyrinth faithfully transduces head motion and gravity in both the time and frequency domains. These signals are described in hopes that they may be prosthetically replicated. The peripheral and central connections of the vestibular nerve are also discussed in detail, as are the vestibular nuclei in the brainstem that receive VIIIth nerve innervation. Lastly, the functional effector pathways of the vestibular system, including the vestibulo-ocular, vestibulo-spinal, vestibulo-colic, vestibulo-autonomic, and vestibular efferent innervation of the labyrinth are reviewed.

Citing Articles

Study on the Perception Mechanism of Utricles Based on Bionic Models.

Jiang Y, Wang X, Lu S, Qin Y, He C, Bian Y Biomimetics (Basel). 2022; 7(1).

PMID: 35323185 PMC: 8945493. DOI: 10.3390/biomimetics7010028.

DISCOHAT: An Acronym to Describe the Spectrum of Symptoms Related to Bilateral Vestibulopathy.

Paredis S, van Stiphout L, Remmen E, Strupp M, Gerards M, Kingma H Front Neurol. 2021; 12:771650.

PMID: 34867759 PMC: 8633101. DOI: 10.3389/fneur.2021.771650.

Peripheral vestibular system: Age-related vestibular loss and associated deficits.

Coto J, Alvarez C, Cejas I, Colbert B, Levin B, Huppert J J Otol. 2021; 16(4):258-265.

PMID: 34548873 PMC: 8438634. DOI: 10.1016/j.joto.2021.06.001.

Novel cell types and developmental lineages revealed by single-cell RNA-seq analysis of the mouse crista ampullaris.

Wilkerson B, Zebroski H, Finkbeiner C, Chitsazan A, Beach K, Sen N Elife. 2021; 10.

PMID: 34003106 PMC: 8189719. DOI: 10.7554/eLife.60108.

Injury of the lateral vestibulospinal tract in a patient with the lateral medullary syndrome: Case report.

Jang S, Park G, Cho I, Yeo S Medicine (Baltimore). 2020; 99(37):e22117.

PMID: 32925758 PMC: 7489691. DOI: 10.1097/MD.0000000000022117.

References

Wersall J . The minute structure of the crista ampullaris in the guinea pig as revealed by the electron microscope. Acta Otolaryngol. 1954; 44(4):359-69. DOI: 10.3109/00016485409128719. View

Highstein S, Rabbitt R, Holstein G, Boyle R . Determinants of spatial and temporal coding by semicircular canal afferents. J Neurophysiol. 2005; 93(5):2359-70. PMC: 3000935. DOI: 10.1152/jn.00533.2004. View

Curthoys I, Oman C . Dimensions of the horizontal semicircular duct, ampulla and utricle in the human. Acta Otolaryngol. 2011; 103(5-6):254-61. DOI: 10.3109/00016488709107791. View

Dickman J, Reder P, Correia M . A method for controlled mechanical stimulation of single semicircular canals. J Neurosci Methods. 1988; 25(2):111-9. DOI: 10.1016/0165-0270(88)90147-1. View

Highstein S, Rabbitt R, Boyle R . Determinants of semicircular canal afferent response dynamics in the toadfish, Opsanus tau. J Neurophysiol. 1996; 75(2):575-96. DOI: 10.1152/jn.1996.75.2.575. View

Bergstrom B . Morphology of the vestibular nerve. I. Anatomical studies of the vestibular nerve in man. Acta Otolaryngol. 1973; 76(2):162-72. DOI: 10.3109/00016487309121495. View

Tricas T, Highstein S . Visually mediated inhibition of lateral line primary afferent activity by the octavolateralis efferent system during predation in the free-swimming toadfish, Opsanus tau. Exp Brain Res. 1990; 83(1):233-6. DOI: 10.1007/BF00232215. View

Tricas T, Highstein S . Action of the octavolateralis efferent system upon the lateral line of free-swimming toadfish, Opsanus tau. J Comp Physiol A. 1991; 169(1):25-37. DOI: 10.1007/BF00198170. View

Honrubia V, Hoffman L, Sitko S, Schwartz I . Anatomic and physiological correlates in bullfrog vestibular nerve. J Neurophysiol. 1989; 61(4):688-701. DOI: 10.1152/jn.1989.61.4.688. View

10.

CORVERA J, HALLPIKE C, Schuster E . A new method for the anatomical reconstruction of the human macular planes. Acta Otolaryngol. 1958; 49(1):4-16. DOI: 10.3109/00016485809134722. View

11.

Miller D, Reighard D, Mehta A, Mehta A, Kalash R, Yates B . Responses of thoracic spinal interneurons to vestibular stimulation. Exp Brain Res. 2009; 195(1):89-100. PMC: 2675666. DOI: 10.1007/s00221-009-1754-0. View

12.

Baird R, Desmadryl G, Fernandez C, Goldberg J . The vestibular nerve of the chinchilla. II. Relation between afferent response properties and peripheral innervation patterns in the semicircular canals. J Neurophysiol. 1988; 60(1):182-203. DOI: 10.1152/jn.1988.60.1.182. View

13.

Hudspeth A . Mechanoelectrical transduction by hair cells in the acousticolateralis sensory system. Annu Rev Neurosci. 1983; 6:187-215. DOI: 10.1146/annurev.ne.06.030183.001155. View

14.

Rabbitt R, Boyle R, Holstein G, Highstein S . Hair-cell versus afferent adaptation in the semicircular canals. J Neurophysiol. 2004; 93(1):424-36. PMC: 3000937. DOI: 10.1152/jn.00426.2004. View

15.

Xiang Y, Yakushin S, Kunin M, Raphan T, Cohen B . Head stabilization by vestibulocollic reflexes during quadrupedal locomotion in monkey. J Neurophysiol. 2008; 100(2):763-80. PMC: 2525722. DOI: 10.1152/jn.90256.2008. View

16.

Goldberg J, Lysakowski A, Fernandez C . Structure and function of vestibular nerve fibers in the chinchilla and squirrel monkey. Ann N Y Acad Sci. 1992; 656:92-107. DOI: 10.1111/j.1749-6632.1992.tb25202.x. View

17.

Rabbitt R, Boyle R, Highstein S . Mechanical amplification by hair cells in the semicircular canals. Proc Natl Acad Sci U S A. 2010; 107(8):3864-9. PMC: 2840494. DOI: 10.1073/pnas.0906765107. View

18.

Wilson V, Schor R . The neural substrate of the vestibulocollic reflex. What needs to be learned. Exp Brain Res. 2000; 129(4):483-93. DOI: 10.1007/s002210050918. View

19.

Highstein S, Baker R . Organization of the efferent vestibular nuclei and nerves of the toadfish, Opsanus tau. J Comp Neurol. 1986; 243(3):309-25. DOI: 10.1002/cne.902430303. View

20.

Igarashi M . Architecture of the otolith end organ: some functional considerations. Ann Otol Rhinol Laryngol. 1966; 75(4):945-55. DOI: 10.1177/000348946607500403. View