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Gay R Holstein

Explore the profile of Gay R Holstein including associated specialties, affiliations and a list of published articles. Areas
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Articles 43
Citations 1123
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Recent Articles
1.
Contini D, Holstein G, Art J
Front Neurol . 2024 Sep; 15:1434026. PMID: 39263277
The vestibular hair cell receptors of anamniotes, designated Type II, are presynaptic to bouton endings of vestibular nerve distal neurites. An additional flask-shaped hair cell receptor, Type I, is present...
2.
Zhou X, Lee Y, Li X, Kim H, Sanchez-Priego C, Han X, et al.
Nat Commun . 2024 Apr; 15(1):3113. PMID: 38600097
Autophagy is a conserved, catabolic process essential for maintaining cellular homeostasis. Malfunctional autophagy contributes to neurodevelopmental and neurodegenerative diseases. However, the exact role and targets of autophagy in human neurons...
3.
Contini D, Holstein G, Art J
Front Neurol . 2022 Jul; 13:891536. PMID: 35899268
In the vestibular periphery, transmission conventional synaptic boutons is supplemented by post-synaptic calyceal endings surrounding Type I hair cells. This review focusses on the multiple modes of communication between these...
4.
Rice D, Martinelli G, Jiang W, Holstein G, Rajguru S
Front Neurol . 2021 Jun; 12:680044. PMID: 34122320
A variety of stimuli activating vestibular end organs, including sinusoidal galvanic vestibular stimulation, whole body rotation and tilt, and head flexion have been shown to evoke significant changes in blood...
5.
Agrawal Y, Merfeld D, Horak F, Redfern M, Manor B, Westlake K, et al.
J Gerontol A Biol Sci Med Sci . 2020 Jul; 75(12):2471-2480. PMID: 32617555
Balance impairment and falls are among the most prevalent and morbid conditions affecting older adults. A critical contributor to balance and gait function is the vestibular system; however, there remain...
6.
Contini D, Holstein G, Art J
J Physiol . 2019 Oct; 598(4):853-889. PMID: 31623011
Key Points: In central regions of vestibular semicircular canal epithelia, the [K ] in the synaptic cleft ([K ] ) contributes to setting the hair cell and afferent membrane potentials;...
7.
Gagliuso A, Chapman E, Martinelli G, Holstein G
J Neurophysiol . 2019 Jun; 122(2):512-524. PMID: 31166818
Anterograde and retrograde tract tracing were combined with neurotransmitter and modulator immunolabeling to identify the chemical anatomy of vestibular nuclear neurons with direct projections to the solitary nucleus in rats....
8.
Holstein G, Friedrich Jr V, Martinelli G
Exp Brain Res . 2016 Jul; 234(10):2747-60. PMID: 27411812
Imidazole-4-acetic acid-ribotide (IAARP) is a putative neurotransmitter/modulator and an endogenous regulator of sympathetic drive, notably systemic blood pressure, through binding to imidazoline receptors. IAARP is present in neurons and processes...
9.
Holstein G, Friedrich Jr V, Martinelli G
Front Neuroanat . 2016 Feb; 10:7. PMID: 26903817
The vestibulo-sympathetic reflex (VSR) actively modulates blood pressure during changes in posture. This reflex allows humans to stand up and quadrupeds to rear or climb without a precipitous decline in...
10.
Lazarus R, Buonora J, Flora M, Freedy J, Holstein G, Martinelli G, et al.
Front Neurol . 2015 Oct; 6:204. PMID: 26441823
Protein citrullination is a calcium-driven post-translational modification proposed to play a causative role in the neurodegenerative disorders of Alzheimer's disease, multiple sclerosis (MS), and prion disease. Citrullination can result in...