The Molecular Basis of T Cell Acute Lymphoblastic Leukemia

Overview

Journal J Clin Invest

Specialty General Medicine

Date 2012 Oct 2

PMID 23023710

Citations 241

Authors

Pieter Van Vlierberghe

Adolfo Ferrando

Affiliations

Soon will be listed here.

Abstract

T cell acute lymphoblastic leukemias (T-ALLs) arise from the malignant transformation of hematopoietic progenitors primed toward T cell development, as result of a multistep oncogenic process involving constitutive activation of NOTCH signaling and genetic alterations in transcription factors, signaling oncogenes, and tumor suppressors. Notably, these genetic alterations define distinct molecular groups of T-ALL with specific gene expression signatures and clinicobiological features. This review summarizes recent advances in our understanding of the molecular genetics of T-ALL.

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