Cerebral Malaria: We Have Come a Long Way

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 2012 Oct 2

PMID 23021981

Citations 43

Authors

Henry J Shikani

Brandi D Freeman

Michael P Lisanti

Louis M Weiss

Herbert B Tanowitz

Mahalia S Desruisseaux

Affiliations

Soon will be listed here.

Abstract

Despite decades of research, cerebral malaria remains one of the most serious complications of Plasmodium infection and is a significant burden in Sub-Saharan Africa, where, despite effective antiparasitic treatment, survivors develop long-term neurological sequelae. Although much remains to be discovered about the pathogenesis of cerebral malaria, The American Journal of Pathology has been seminal in presenting original research from both human and experimental models. These studies have afforded significant insight into the mechanism of cerebral damage in this devastating disease. The present review highlights information gleaned from these studies, especially in terms of their contributions to the understanding of cerebral malaria.

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