Three-dimensional Brain Phantom Containing Bone and Grey Matter Structures with a Realistic Head Contour

Overview

Journal Ann Nucl Med

Date 2012 Sep 27

PMID 23011903

Citations 25

Authors

Hidehiro Iida

Yuki Hori

Kenji Ishida

Etsuko Imabayashi

Hiroshi Matsuda

Masaaki Takahashi

Hirotaka Maruno

Akihide Yamamoto

Kazuhiro Koshino

Junichiro Enmi

Satoshi Iguchi

Tetsuaki Moriguchi

Hidekazu Kawashima

Tsutomu Zeniya

Affiliations

Soon will be listed here.

Abstract

Introduction: A physical 3-dimensional phantom that simulates PET/SPECT images of static regional cerebral blood flow in grey matter with a realistic head contour has been developed. This study examined the feasibility of using this phantom for evaluating PET/SPECT images.

Methods: The phantom was constructed using a transparent, hydrophobic photo-curable polymer with a laser-modelling technique. The phantom was designed to contain the grey matter, the skull, and the trachea spaces filled with a radioactive solution, a bone-equivalent solution of K(2)HPO(4), and air, respectively. The grey matter and bone compartments were designed to establish the connectivity. A series of experiments was performed to confirm the accuracy and reproducibility of the phantom using X-ray CT, SPECT, and PET.

Results: The total weight was 1997 ± 2 g excluding the inner liquid, and volumes were 563 ± 1 and 306 ± 2 mL, corresponding to the grey matter and bone compartments, respectively. The apparent attenuation coefficient averaged over the whole brain was 0.168 ± 0.006 cm(-1) for Tc-99 m, which was consistent with the previously reported value for humans (0.168 ± 0.010 cm(-1)). Air bubbles were well removed from both grey-matter and bone compartments, as confirmed by X-ray CT. The phantom was well adapted to experiments using PET and SPECT devices.

Conclusion: The 3-dimensional brain phantom constructed in this study may be of use for evaluating the adequacy of SPECT/PET reconstruction software programs.

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