Wearable and Implantable Pancreas Substitutes

Overview

Journal J Artif Organs

Specialty Biomedical Engineering

Date 2012 Sep 20

PMID 22990986

Citations 9

Authors

Leonardo Ricotti

Tareq Assaf

Paolo Dario

Arianna Menciassi

Affiliations

Soon will be listed here.

Abstract

A lifelong-implanted and completely automated artificial or bioartificial pancreas (BAP) is the holy grail for type 1 diabetes treatment, and could be a definitive solution even for other severe pathologies, such as pancreatitis and pancreas cancer. Technology has made several important steps forward in the last years, providing new hope for the realization of such devices, whose feasibility is strictly connected to advances in glucose sensor technology, subcutaneous and intraperitoneal insulin pump development, the design of closed-loop control algorithms for mechatronic pancreases, as well as cell and tissue engineering and cell encapsulation for biohybrid pancreases. Furthermore, smart integration of the mentioned components and biocompatibility issues must be addressed, bearing in mind that, for mechatronic pancreases, it is most important to consider how to recharge implanted batteries and refill implanted insulin reservoirs without requiring periodic surgical interventions. This review describes recent advancements in technologies and concepts related to artificial and bioartificial pancreases, and assesses how far we are from a lifelong-implanted and self-working pancreas substitute that can fully restore the quality of life of a diabetic (or other type of) patient.

Citing Articles

Characterization of Cyclic Olefin Copolymers for Insulin Reservoir in an Artificial Pancreas.

Mallegni N, Milazzo M, Cristallini C, Barbani N, Fredi G, Dorigato A J Funct Biomater. 2023; 14(3).

PMID: 36976069 PMC: 10053537. DOI: 10.3390/jfb14030145.

Effect of sensor location on continuous intraperitoneal glucose sensing in an animal model.

Am M, Kolle K, Fougner A, Dirnena-Fusini I, Bosch P, Ellingsen R PLoS One. 2018; 13(10):e0205447.

PMID: 30300416 PMC: 6177183. DOI: 10.1371/journal.pone.0205447.

Investigation of drug release modulation from poly(2-oxazoline) micelles through ultrasound.

Salgarella A, Zahoranova A, Sramkova P, Majercikova M, Pavlova E, Luxenhofer R Sci Rep. 2018; 8(1):9893.

PMID: 29967422 PMC: 6028437. DOI: 10.1038/s41598-018-28140-3.

Clinical results of an automated artificial pancreas using technosphere inhaled insulin to mimic first-phase insulin secretion.

Zisser H, Dassau E, Lee J, Harvey R, Bevier W, Doyle 3rd F J Diabetes Sci Technol. 2015; 9(3):564-72.

PMID: 25901023 PMC: 4604530. DOI: 10.1177/1932296815582061.

Mind-controlled transgene expression by a wireless-powered optogenetic designer cell implant.

Folcher M, Oesterle S, Zwicky K, Thekkottil T, Heymoz J, Hohmann M Nat Commun. 2014; 5:5392.

PMID: 25386727 PMC: 4241983. DOI: 10.1038/ncomms6392.

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