Interplay Between Vitamin D and the Drug Metabolizing Enzyme CYP3A4

Overview

Journal J Steroid Biochem Mol Biol

Specialties Biochemistry
Molecular Biology

Date 2012 Sep 19

PMID 22985909

Citations 56

Authors

Zhican Wang

Erin G Schuetz

Yang Xu

Kenneth E Thummel

Affiliations

Soon will be listed here.

Abstract

Cytochrome P450 3A4 (CYP3A4) is a multifunctional enzyme involved in both xenobiotic and endobiotic metabolism. This review focuses on two aspects: regulation of CYP3A4 expression by vitamin D and metabolism of vitamin D by CYP3A4. Enterohepatic circulation of vitamin D metabolites and their conjugates will be also discussed. The interplay between vitamin D and CYP3A4 provides new insights into our understanding of how enzyme induction can contribute to vitamin D deficiency. This article is part of a Special Issue entitled 'Vitamin D Workshop'.

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