Crohn's Disease Susceptibility Genes Are Associated with Leprosy in the Vietnamese Population

Overview

Journal J Infect Dis

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2012 Sep 18

PMID 22984114

Citations 42

Authors

Audrey V Grant

Andrea Alter

Nguyen Thu Huong

Marianna Orlova

Nguyen Van Thuc

Nguyen Ngoc Ba

Vu Hong Thai

Laurent Abel

Erwin Schurr

Alexandre Alcais

Affiliations

Soon will be listed here.

Abstract

A genomewide association study in Chinese patients with leprosy detected association signals in 16 single-nucleotide polymorphisms (SNPs) belonging to 6 loci, of which 4 are related to the NOD2 signaling pathway and are Crohn's disease susceptibility loci. Here, we studied these 16 SNPs as potential leprosy susceptibility factors in 474 Vietnamese leprosy simplex families. We replicated SNPs at HLA-DR-DQ, RIPK2, CCDC122-LACC1, and NOD2 as leprosy susceptibility factors in Vietnam. These results validated the striking overlap in the genetic control of Crohn's disease and leprosy.

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Dallmann-Sauer M, Xu Y, da Costa A, Tao S, Gomes T, Prata R PLoS Pathog. 2023; 19(3):e1011260.

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Bustos M, Castaneda-Castaneda L, Acosta C, Garcia D, Bohada D, Rodriguez R PLoS One. 2023; 18(3):e0281553.

PMID: 36877680 PMC: 9987820. DOI: 10.1371/journal.pone.0281553.