Screening of Promising Chemotherapeutic Candidates from Plants Against Human Adult T-cell Leukemia/lymphoma (II): Apoptosis of Antiproliferactive Principle (24,25-dihydrowithanolide D) Against ATL Cell Lines and Structure-activity Relationships With...

Overview

Journal J Nat Med

Publisher Springer

Date 2012 Sep 11

PMID 22961603

Citations 7

Authors

Daisuke Nakano

Kenji Ishitsuka

Hiroo Katsuya

Naoko Kunami

Rumiko Nogami

Yuka Yoshimura

Michika Matsuda

Mio Kamikawa

Ryota Tsuchihashi

Masafumi Okawa

Tsuyoshi Ikeda

Toshihiro Nohara

Kazuo Tamura

Junei Kinjo

Affiliations

Soon will be listed here.

Abstract

Adult T-cell leukemia/lymphoma (ATL) is an incurable peripheral T-cell malignancy caused by human T-cell lymphotropic virus type I. In our preceding paper, 214 extracts from 162 plants were screened to elucidate the antiproliferative principles against ATL cell lines. Several withanolides were isolated and the structure-activity relationships (SAR) examined. To extend the search for SAR, 31 further withanolides, previously isolated from solanaceous plants, were tested against ATL cell lines. The presence of a 4β-hydroxy group as well as a 5β,6β-epoxy group appeared to be essential for the activity. In contrast, the presence of a sugar moiety at either the 3- or the 27-position led to a reduction in the activity. Furthermore, 24,25-dihydrowithanolide D (13) was identified as the most potent inhibitor, showing selective toxicity against ATL cell lines by inducing apoptotic cell death.

Citing Articles

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (VIII): six new withanolides from Physalis philadelphica.

Nakano D, Ishitsuka K, Deishi Y, Tsuchihashi R, Kinjo J, Nohara T J Nat Med. 2023; 77(4):688-698.

PMID: 37202653 DOI: 10.1007/s11418-023-01705-x.

Screening of Promising Chemotherapeutic Candidates from Plants against Human Adult T-Cell Leukemia/Lymphoma (VII): Active Principles from L.

Nakano D, Ishitsuka K, Ishihara M, Tsuchihashi R, Okawa M, Tamura K Molecules. 2021; 26(24).

PMID: 34946696 PMC: 8707666. DOI: 10.3390/molecules26247619.

Investigating 11 Withanosides and Withanolides by UHPLC-PDA and Mass Fragmentation Studies from Ashwagandha ().

Girme A, Saste G, Pawar S, Balasubramaniam A, Musande K, Darji B ACS Omega. 2020; 5(43):27933-27943.

PMID: 33163776 PMC: 7643146. DOI: 10.1021/acsomega.0c03266.

Screening of promising chemotherapeutic candidates from plants against human adult T-cell leukemia/lymphoma (V): coumarins and alkaloids from Boenninghausenia japonica and Ruta graveolens.

Nakano D, Ishitsuka K, Matsuda N, Kouguchi A, Tsuchihashi R, Okawa M J Nat Med. 2016; 71(1):170-180.

PMID: 27738859 DOI: 10.1007/s11418-016-1046-5.

Screening of promising chemotherapeutic candidates from plants extracts.

Kinjo J, Nakano D, Fujioka T, Okabe H J Nat Med. 2016; 70(3):335-60.

PMID: 27086008 PMC: 4935755. DOI: 10.1007/s11418-016-0992-2.

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