Neurological Perspectives on Voltage-gated Sodium Channels

Overview

Journal Brain

Publisher Oxford University Press

Specialty Neurology

Date 2012 Sep 11

PMID 22961543

Citations 144

Authors

Niels Eijkelkamp

John E Linley

Mark D Baker

Michael S Minett

Roman Cregg

Robert Werdehausen

Francois Rugiero

John N Wood

Affiliations

Soon will be listed here.

Abstract

The activity of voltage-gated sodium channels has long been linked to disorders of neuronal excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded the role of sodium channels in health and disease, to include autism, migraine, multiple sclerosis, cancer as well as muscle and immune system disorders. Transgenic mouse models have proved useful in understanding the physiological role of individual sodium channels, and there has been significant progress in the development of subtype selective inhibitors of sodium channels. This review will outline the functions and roles of specific sodium channels in electrical signalling and disease, focusing on neurological aspects. We also discuss recent advances in the development of selective sodium channel inhibitors.

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References

Carter A . The importance of voltage-dependent sodium channels in cerebral ischaemia. Amino Acids. 1999; 14(1-3):159-69. DOI: 10.1007/BF01345257. View

Fertleman C, Baker M, Parker K, Moffatt S, Elmslie F, Abrahamsen B . SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes. Neuron. 2006; 52(5):767-74. DOI: 10.1016/j.neuron.2006.10.006. View

Alabi A, Bahamonde M, Jung H, Kim J, Swartz K . Portability of paddle motif function and pharmacology in voltage sensors. Nature. 2007; 450(7168):370-5. PMC: 2709416. DOI: 10.1038/nature06266. View

Brittain J, Duarte D, Wilson S, Zhu W, Ballard C, Johnson P . Suppression of inflammatory and neuropathic pain by uncoupling CRMP-2 from the presynaptic Ca²⁺ channel complex. Nat Med. 2011; 17(7):822-9. PMC: 3219927. DOI: 10.1038/nm.2345. View

Brackenbury W, Calhoun J, Chen C, Miyazaki H, Nukina N, Oyama F . Functional reciprocity between Na+ channel Nav1.6 and beta1 subunits in the coordinated regulation of excitability and neurite outgrowth. Proc Natl Acad Sci U S A. 2010; 107(5):2283-8. PMC: 2836661. DOI: 10.1073/pnas.0909434107. View

Schiavon E, Sacco T, Cassulini R, Gurrola G, Tempia F, Possani L . Resurgent current and voltage sensor trapping enhanced activation by a beta-scorpion toxin solely in Nav1.6 channel. Significance in mice Purkinje neurons. J Biol Chem. 2006; 281(29):20326-37. DOI: 10.1074/jbc.M600565200. View

Goldin A, Barchi R, Caldwell J, Hofmann F, Howe J, Hunter J . Nomenclature of voltage-gated sodium channels. Neuron. 2001; 28(2):365-8. DOI: 10.1016/s0896-6273(00)00116-1. View

Mantegazza M, Curia G, Biagini G, Ragsdale D, Avoli M . Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol. 2010; 9(4):413-24. DOI: 10.1016/S1474-4422(10)70059-4. View

Wang Y, Khanna R . VOLTAGE-GATED CALCIUM CHANNELS ARE NOT AFFECTED BY THE NOVEL ANTI-EPILEPTIC DRUG LACOSAMIDE. Transl Neurosci. 2011; 2(1):13-22. PMC: 3178266. DOI: 10.2478/s13380-011-0002-9. View

10.

ORoak B, Vives L, Girirajan S, Karakoc E, Krumm N, Coe B . Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature. 2012; 485(7397):246-50. PMC: 3350576. DOI: 10.1038/nature10989. View

11.

Cattaneo A . Tanezumab, a recombinant humanized mAb against nerve growth factor for the treatment of acute and chronic pain. Curr Opin Mol Ther. 2010; 12(1):94-106. View

12.

Westenbroek R, Merrick D, Catterall W . Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons. Neuron. 1989; 3(6):695-704. DOI: 10.1016/0896-6273(89)90238-9. View

13.

Theile J, Jarecki B, Piekarz A, Cummins T . Nav1.7 mutations associated with paroxysmal extreme pain disorder, but not erythromelalgia, enhance Navbeta4 peptide-mediated resurgent sodium currents. J Physiol. 2010; 589(Pt 3):597-608. PMC: 3055545. DOI: 10.1113/jphysiol.2010.200915. View

14.

Kudrow L, Kudrow D, Sandweiss J . Rapid and sustained relief of migraine attacks with intranasal lidocaine: preliminary findings. Headache. 1995; 35(2):79-82. DOI: 10.1111/j.1526-4610.1995.hed3502079.x. View

15.

Grieco T, Malhotra J, Chen C, Isom L, Raman I . Open-channel block by the cytoplasmic tail of sodium channel beta4 as a mechanism for resurgent sodium current. Neuron. 2005; 45(2):233-44. DOI: 10.1016/j.neuron.2004.12.035. View

16.

Kaplan M, Cho M, Ullian E, Isom L, Levinson S, Barres B . Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of Ranvier. Neuron. 2001; 30(1):105-19. DOI: 10.1016/s0896-6273(01)00266-5. View

17.

Mao J, Chen L . Systemic lidocaine for neuropathic pain relief. Pain. 2000; 87(1):7-17. DOI: 10.1016/S0304-3959(00)00229-3. View

18.

Zona C, Tancredi V, Longone P, DArcangelo G, DAntuono M, Manfredi M . Neocortical potassium currents are enhanced by the antiepileptic drug lamotrigine. Epilepsia. 2002; 43(7):685-90. DOI: 10.1046/j.1528-1157.2002.51401.x. View

19.

Fang X, Djouhri L, Black J, Dib-Hajj S, Waxman S, Lawson S . The presence and role of the tetrodotoxin-resistant sodium channel Na(v)1.9 (NaN) in nociceptive primary afferent neurons. J Neurosci. 2002; 22(17):7425-33. PMC: 6757987. View

20.

Catterall W . From ionic currents to molecular mechanisms: the structure and function of voltage-gated sodium channels. Neuron. 2000; 26(1):13-25. DOI: 10.1016/s0896-6273(00)81133-2. View