Candidate Polymorphisms and Severe Malaria in a Malian Population

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2012 Sep 8

PMID 22957039

Citations 28

Authors

Ousmane Toure

Salimata Konate

Sibiri Sissoko

Amadou Niangaly

Abdoulaye Barry

Abdourahmane H Sall

Elisabeth Diarra

Belco Poudiougou

Nuno Sepulveda

Susana Campino

Kirk A Rockett

Taane G Clark

Mahamadou A Thera

Ogobara Doumbo

Affiliations

Soon will be listed here.

Abstract

Malaria is a major health burden in sub-Saharan African countries, including Mali. The disease is complex, with multiple genetic determinants influencing the observed variation in response to infection, progression, and severity. We assess the influence of sixty-four candidate loci, including the sickle cell polymorphism (HbS), on severe malaria in a case-control study consisting of over 900 individuals from Bamako, Mali. We confirm the known protective effects of the blood group O and the HbS AS genotype on life-threatening malaria. In addition, our analysis revealed a marginal susceptibility effect for the CD40 ligand (CD40L)+220C allele. The lack of statistical evidence for other candidates may demonstrate the need for large-scale genome-wide association studies in malaria to discover new polymorphisms. It also demonstrates the need for establishing the region-specific repertoire of functional variation in important genes, including the glucose-6-phosphatase deficiency gene, before embarking on focused genotyping.

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References

Modiano D, Petrarca V, Sirima B, Bosman A, Nebie I, Diallo D . Plasmodium falciparum malaria in sympatric ethnic groups of Burkina Faso, west Africa. Parassitologia. 1995; 37(2-3):255-9. View

. Severe and complicated malaria. World Health Organization, Division of Control of Tropical Diseases. Trans R Soc Trop Med Hyg. 1990; 84 Suppl 2:1-65. View

Rowe J, Handel I, Thera M, Deans A, Lyke K, Kone A . Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting. Proc Natl Acad Sci U S A. 2007; 104(44):17471-6. PMC: 2077280. DOI: 10.1073/pnas.0705390104. View

Fry A, Griffiths M, Auburn S, Diakite M, Forton J, Green A . Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Hum Mol Genet. 2007; 17(4):567-76. PMC: 2657867. DOI: 10.1093/hmg/ddm331. View

Mackinnon M, Mwangi T, Snow R, Marsh K, Williams T . Heritability of malaria in Africa. PLoS Med. 2005; 2(12):e340. PMC: 1277928. DOI: 10.1371/journal.pmed.0020340. View

Wilson J, Rockett K, Jallow M, Pinder M, Sisay-Joof F, Newport M . Analysis of IL10 haplotypic associations with severe malaria. Genes Immun. 2005; 6(6):462-6. DOI: 10.1038/sj.gene.6364227. View

Sabeti P, Usen S, Farhadian S, Jallow M, Doherty T, Newport M . CD40L association with protection from severe malaria. Genes Immun. 2002; 3(5):286-91. DOI: 10.1038/sj.gene.6363877. View

Clark I, Rockett K . Nitric oxide and parasitic disease. Adv Parasitol. 1996; 37:1-56. DOI: 10.1016/s0065-308x(08)60218-3. View

Stevenson M, Riley E . Innate immunity to malaria. Nat Rev Immunol. 2004; 4(3):169-80. DOI: 10.1038/nri1311. View

10.

Clark T, Diakite M, Auburn S, Campino S, Fry A, Green A . Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. J Infect Dis. 2009; 199(4):569-75. PMC: 2742199. DOI: 10.1086/596320. View

11.

Campino S, Kwiatkowski D, Dessein A . Mendelian and complex genetics of susceptibility and resistance to parasitic infections. Semin Immunol. 2006; 18(6):411-22. DOI: 10.1016/j.smim.2006.07.011. View

12.

Jallow M, Teo Y, Small K, Rockett K, Deloukas P, Clark T . Genome-wide and fine-resolution association analysis of malaria in West Africa. Nat Genet. 2009; 41(6):657-65. PMC: 2889040. DOI: 10.1038/ng.388. View

13.

Guindo A, Fairhurst R, Doumbo O, Wellems T, Diallo D . X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria. PLoS Med. 2007; 4(3):e66. PMC: 1820604. DOI: 10.1371/journal.pmed.0040066. View

14.

Agarwal A, Guindo A, Cissoko Y, Taylor J, Coulibaly D, Kone A . Hemoglobin C associated with protection from severe malaria in the Dogon of Mali, a West African population with a low prevalence of hemoglobin S. Blood. 2000; 96(7):2358-63. View

15.

Mockenhaupt F, Hamann L, von Gaertner C, Bedu-Addo G, von Kleinsorgen C, Schumann R . Common polymorphisms of toll-like receptors 4 and 9 are associated with the clinical manifestation of malaria during pregnancy. J Infect Dis. 2006; 194(2):184-8. DOI: 10.1086/505152. View

16.

Clark T, Fry A, Auburn S, Campino S, Diakite M, Green A . Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility. Eur J Hum Genet. 2009; 17(8):1080-5. PMC: 2986558. DOI: 10.1038/ejhg.2009.8. View

17.

Dolo A, Modiano D, Maiga B, Daou M, Dolo G, Guindo H . Difference in susceptibility to malaria between two sympatric ethnic groups in Mali. Am J Trop Med Hyg. 2005; 72(3):243-8. View

18.

Zhang L, Cui X, Schmitt K, Hubert R, Navidi W, Arnheim N . Whole genome amplification from a single cell: implications for genetic analysis. Proc Natl Acad Sci U S A. 1992; 89(13):5847-51. PMC: 49394. DOI: 10.1073/pnas.89.13.5847. View

19.

Marsh K, Forster D, Waruiru C, Mwangi I, Winstanley M, Marsh V . Indicators of life-threatening malaria in African children. N Engl J Med. 1995; 332(21):1399-404. DOI: 10.1056/NEJM199505253322102. View

20.

Diakite M, Clark T, Auburn S, Campino S, Fry A, Green A . A genetic association study in the Gambia using tagging polymorphisms in the major histocompatibility complex class III region implicates a HLA-B associated transcript 2 polymorphism in severe malaria susceptibility. Hum Genet. 2008; 125(1):105-9. PMC: 2992315. DOI: 10.1007/s00439-008-0597-2. View