A Sexual Ornament in Chickens is Affected by Pleiotropic Alleles at HAO1 and BMP2, Selected During Domestication

Overview

Journal PLoS Genet

Specialty Genetics

Date 2012 Sep 8

PMID 22956912

Citations 34

Authors

Martin Johnsson

Ida Gustafson

Carl-Johan Rubin

Anna-Stina Sahlqvist

Kenneth B Jonsson

Susanne Kerje

Olov Ekwall

Olle Kampe

Leif Andersson

Per Jensen

Dominic Wright

Affiliations

Soon will be listed here.

Abstract

Domestication is one of the strongest forms of short-term, directional selection. Although selection is typically only exerted on one or a few target traits, domestication can lead to numerous changes in many seemingly unrelated phenotypes. It is unknown whether such correlated responses are due to pleiotropy or linkage between separate genetic architectures. Using three separate intercrosses between wild and domestic chickens, a locus affecting comb mass (a sexual ornament in the chicken) and several fitness traits (primarily medullary bone allocation and fecundity) was identified. This locus contains two tightly-linked genes, BMP2 and HAO1, which together produce the range of pleiotropic effects seen. This study demonstrates the importance of pleiotropy (or extremely close linkage) in domestication. The nature of this pleiotropy also provides insights into how this sexual ornament could be maintained in wild populations.

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