In Vitro Activities of Nine Antifungal Drugs Against 81 Phialophora and Cyphellophora Isolates

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2012 Sep 6

PMID 22948876

Citations 11

Authors

Peiying Feng

M Javad Najafzadeh

Jiufeng Sun

Sarah Ahmed

Liyan Xi

G Sybren de Hoog

Wei Lai

Chun Lu

Corne H Klaassen

Jacques F Meis

Affiliations

Soon will be listed here.

Abstract

Cyphellophora guyanensis (n = 15), other Cyphellophora species (n = 11), Phialophora europaea (n = 43), and other Phialophora species (n = 12) were tested in vitro against nine antifungal drugs. The MIC(90)s across all of the strains (n = 81) were, in increasing order, as follows: posaconazole, 0.063 μg/ml; itraconazole, 0.5 μg/ml; voriconazole, 1 μg/ml; micafungin, 1 μg/ml; terbinafine, 2 μg/ml; isavuconazole, 4 μg/ml; caspofungin, 4 μg/ml; fluconazole, 8 μg/ml; amphotericin B, 16 μg/ml.

Citing Articles

sp. Isolated from a Corneal Ulcer in the Human Eye.

Rajandran S, Razali K, Mustapha M, Palaniappan P, Amran F Case Rep Ophthalmol Med. 2020; 2020:5861258.

PMID: 32774963 PMC: 7395999. DOI: 10.1155/2020/5861258.

A Case of Chromoblastomycosis Caused by Fonsecaea pedrosoi Successfully Treated by Oral Itraconazole Together with Terbinafine.

Shen X, Dai X, Xie Z, Li P, Lu S, Li J Dermatol Ther (Heidelb). 2020; 10(2):321-327.

PMID: 32086748 PMC: 7090106. DOI: 10.1007/s13555-020-00358-y.

Photodynamic therapy combined with antifungal drugs against chromoblastomycosis and the effect of ALA-PDT on Fonsecaea in vitro.

Hu Y, Qi X, Sun H, Lu Y, Hu Y, Chen X PLoS Negl Trop Dis. 2019; 13(10):e0007849.

PMID: 31671098 PMC: 6850556. DOI: 10.1371/journal.pntd.0007849.

Indoor wet cells as a habitat for melanized fungi, opportunistic pathogens on humans and other vertebrates.

Wang X, Cai W, Gerrits van den Ende A, Zhang J, Xie T, Xi L Sci Rep. 2018; 8(1):7685.

PMID: 29769615 PMC: 5955924. DOI: 10.1038/s41598-018-26071-7.

Chromoblastomycosis.

Queiroz-Telles F, de Hoog S, Santos D, Salgado C, Vicente V, Bonifaz A Clin Microbiol Rev. 2016; 30(1):233-276.

PMID: 27856522 PMC: 5217794. DOI: 10.1128/CMR.00032-16.

References

Hamada N, Abe N . Growth characteristics of four fungal species in bathrooms. Biocontrol Sci. 2010; 15(3):111-5. DOI: 10.4265/bio.15.111. View

Sutton B, Campbell C, Goldschmied-Reouven A . Pseudomicrodochium fusarioides sp. nov., isolated from human bronchial fluid. Mycopathologia. 1991; 114(3):159-61. DOI: 10.1007/BF00437207. View

Yamazaki T, Inagaki Y, Fujii T, Ohwada J, Tsukazaki M, Umeda I . In vitro activity of isavuconazole against 140 reference fungal strains and 165 clinically isolated yeasts from Japan. Int J Antimicrob Agents. 2010; 36(4):324-31. DOI: 10.1016/j.ijantimicag.2010.06.003. View

Badali H, de Hoog G, Curfs-Breuker I, Meis J . In vitro activities of antifungal drugs against Rhinocladiella mackenziei, an agent of fatal brain infection. J Antimicrob Chemother. 2009; 65(1):175-7. DOI: 10.1093/jac/dkp390. View

Decock C, Delgado-Rodriguez G, Buchet S, Seng J . A new species and three new combinations in Cyphellophora, with a note on the taxonomic affinities of the genus, and its relation to Kumbhamaya and Pseudomicrodochium. Antonie Van Leeuwenhoek. 2003; 84(3):209-16. DOI: 10.1023/a:1026015031851. View

Perfect J, Schell W . The new fungal opportunists are coming. Clin Infect Dis. 1996; 22 Suppl 2:S112-8. DOI: 10.1093/clinids/22.supplement_2.s112. View

Lian X, de Hoog G . Indoor wet cells harbour melanized agents of cutaneous infection. Med Mycol. 2010; 48(4):622-8. DOI: 10.3109/13693780903405774. View

de Hoog G, Vicente V, Najafzadeh M, Harrak M, Badali H, Seyedmousavi S . Waterborne Exophiala species causing disease in cold-blooded animals. Persoonia. 2012; 27:46-72. PMC: 3251318. DOI: 10.3767/003158511X614258. View

Saunte D, Tarazooie B, Arendrup M, de Hoog G . Black yeast-like fungi in skin and nail: it probably matters. Mycoses. 2011; 55(2):161-7. DOI: 10.1111/j.1439-0507.2011.02055.x. View

10.

de Hoog G, Mayser P, Haase G, Horre R, Horrevorts A . A new species, Phialophora europaea, causing superficial infections in humans. Mycoses. 2001; 43(11-12):409-16. DOI: 10.1046/j.1439-0507.2000.00601.x. View

11.

Guinea J, Bouza E . Isavuconazole: a new and promising antifungal triazole for the treatment of invasive fungal infections. Future Microbiol. 2008; 3(6):603-15. DOI: 10.2217/17460913.3.6.603. View

12.

Eckhard M, Lengler A, Liersch J, Bretzel R, Mayser P . Fungal foot infections in patients with diabetes mellitus--results of two independent investigations. Mycoses. 2007; 50 Suppl 2:14-9. DOI: 10.1111/j.1439-0507.2007.01425.x. View

13.

Bittencourt A, Machado P, Araujo M . Subcutaneous phaeohyphomycosis caused by Cyphellophora pluriseptata. Eur J Dermatol. 2002; 12(1):103-6. View

14.

DE VRIES G, Elders M, Luykx M . Description of Cyphellophora pluriseptata sp. nov. Antonie Van Leeuwenhoek. 1986; 52(2):141-3. DOI: 10.1007/BF00429317. View

15.

Najafzadeh M, Badali H, Illnait-Zaragozi M, de Hoog G, Meis J . In vitro activities of eight antifungal drugs against 55 clinical isolates of Fonsecaea spp. Antimicrob Agents Chemother. 2010; 54(4):1636-8. PMC: 2849378. DOI: 10.1128/AAC.01655-09. View

16.

Badali H, de Hoog G, Curfs-Breuker I, Klaassen C, Meis J . Use of amplified fragment length polymorphism to identify 42 Cladophialophora strains related to cerebral phaeohyphomycosis with in vitro antifungal susceptibility. J Clin Microbiol. 2010; 48(7):2350-6. PMC: 2897533. DOI: 10.1128/JCM.00653-10. View

17.

Thompson 3rd G, Wiederhold N . Isavuconazole: a comprehensive review of spectrum of activity of a new triazole. Mycopathologia. 2010; 170(5):291-313. DOI: 10.1007/s11046-010-9324-3. View

18.

Ameen M . Epidemiology of superficial fungal infections. Clin Dermatol. 2010; 28(2):197-201. DOI: 10.1016/j.clindermatol.2009.12.005. View