Reconstruction of Fetal Brain MRI with Intensity Matching and Complete Outlier Removal

Overview

Journal Med Image Anal

Publisher Elsevier

Specialty Radiology

Date 2012 Sep 4

PMID 22939612

Citations 150

Authors

Maria Kuklisova-Murgasova

Gerardine Quaghebeur

Mary A Rutherford

Joseph V Hajnal

Julia A Schnabel

Affiliations

Soon will be listed here.

Abstract

We propose a method for the reconstruction of volumetric fetal MRI from 2D slices, comprising super-resolution reconstruction of the volume interleaved with slice-to-volume registration to correct for the motion. The method incorporates novel intensity matching of acquired 2D slices and robust statistics which completely excludes identified misregistered or corrupted voxels and slices. The reconstruction method is applied to motion-corrupted data simulated from MRI of a preterm neonate, as well as 10 clinically acquired thick-slice fetal MRI scans and three scan-sequence optimized thin-slice fetal datasets. The proposed method produced high quality reconstruction results from all the datasets to which it was applied. Quantitative analysis performed on simulated and clinical data shows that both intensity matching and robust statistics result in statistically significant improvement of super-resolution reconstruction. The proposed novel EM-based robust statistics also improves the reconstruction when compared to previously proposed Huber robust statistics. The best results are obtained when thin-slice data and the correct approximation of the point spread function is used. This paper addresses the need for a comprehensive reconstruction algorithm of 3D fetal MRI, so far lacking in the scientific literature.

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