Mitochondrial Fission, Fusion, and Stress

Overview

Journal Science

Specialty Science

Date 2012 Sep 1

PMID 22936770

Citations 1674

Authors

Richard J Youle

Alexander M van der Bliek

Affiliations

Soon will be listed here.

Abstract

Mitochondrial fission and fusion play critical roles in maintaining functional mitochondria when cells experience metabolic or environmental stresses. Fusion helps mitigate stress by mixing the contents of partially damaged mitochondria as a form of complementation. Fission is needed to create new mitochondria, but it also contributes to quality control by enabling the removal of damaged mitochondria and can facilitate apoptosis during high levels of cellular stress. Disruptions in these processes affect normal development, and they have been implicated in neurodegenerative diseases, such as Parkinson's.

Citing Articles

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