Induced Pluripotent Stem Cells and Their Potential for Basic and Clinical Sciences

Overview

Journal Curr Cardiol Rev

Publisher Bentham Science Publishers

Specialty Cardiology & Vascular Diseases

Date 2012 Sep 1

PMID 22935022

Citations 46

Authors

Lei Ye

Cory Swingen

Jianyi Zhang

Affiliations

Soon will be listed here.

Abstract

Induced pluripotent stem (iPS) cells, are a type of pluripotent stem cell derived from adult somatic cells. They have been reprogrammed through inducing genes and factors to be pluripotent. iPS cells are similar to embryonic stem (ES) cells in many aspects. This review summarizes the recent progresses in iPS cell reprogramming and iPS cell based therapy, and describe patient specific iPS cells as a disease model at length in the light of the literature. This review also analyzes and discusses the problems and considerations of iPS cell therapy in the clinical perspective for the treatment of disease.

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References

Sugii S, Kida Y, Berggren W, Evans R . Feeder-dependent and feeder-independent iPS cell derivation from human and mouse adipose stem cells. Nat Protoc. 2011; 6(3):346-58. PMC: 3089977. DOI: 10.1038/nprot.2010.199. View

Huangfu D, Osafune K, Maehr R, Guo W, Eijkelenboom A, Chen S . Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2. Nat Biotechnol. 2008; 26(11):1269-75. DOI: 10.1038/nbt.1502. View

Lee G, Papapetrou E, Kim H, Chambers S, Tomishima M, Fasano C . Modelling pathogenesis and treatment of familial dysautonomia using patient-specific iPSCs. Nature. 2009; 461(7262):402-6. PMC: 2784695. DOI: 10.1038/nature08320. View

Okahara-Narita J, Umeda R, Nakamura S, Mori T, Noce T, Torii R . Induction of pluripotent stem cells from fetal and adult cynomolgus monkey fibroblasts using four human transcription factors. Primates. 2011; 53(2):205-13. DOI: 10.1007/s10329-011-0283-1. View

Montserrat N, de Onate L, Garreta E, Gonzalez F, Adamo A, Eguizabal C . Generation of feeder-free pig induced pluripotent stem cells without Pou5f1. Cell Transplant. 2011; 21(5):815-25. DOI: 10.3727/096368911X601019. View

Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M . Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc Jpn Acad Ser B Phys Biol Sci. 2009; 85(8):348-62. PMC: 3621571. DOI: 10.2183/pjab.85.348. View

Chambers S, Fasano C, Papapetrou E, Tomishima M, Sadelain M, Studer L . Highly efficient neural conversion of human ES and iPS cells by dual inhibition of SMAD signaling. Nat Biotechnol. 2009; 27(3):275-80. PMC: 2756723. DOI: 10.1038/nbt.1529. View

Narsinh K, Jia F, Robbins R, Kay M, Longaker M, Wu J . Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors. Nat Protoc. 2011; 6(1):78-88. PMC: 3657506. DOI: 10.1038/nprot.2010.173. View

Okita K, Ichisaka T, Yamanaka S . Generation of germline-competent induced pluripotent stem cells. Nature. 2007; 448(7151):313-7. DOI: 10.1038/nature05934. View

10.

Matsa E, Rajamohan D, Dick E, Young L, Mellor I, Staniforth A . Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J. 2011; 32(8):952-62. PMC: 3076668. DOI: 10.1093/eurheartj/ehr073. View

11.

Liu H, Zhu F, Yong J, Zhang P, Hou P, Li H . Generation of induced pluripotent stem cells from adult rhesus monkey fibroblasts. Cell Stem Cell. 2008; 3(6):587-90. DOI: 10.1016/j.stem.2008.10.014. View

12.

Honda A, Hirose M, Hatori M, Matoba S, Miyoshi H, Inoue K . Generation of induced pluripotent stem cells in rabbits: potential experimental models for human regenerative medicine. J Biol Chem. 2010; 285(41):31362-9. PMC: 2951210. DOI: 10.1074/jbc.M110.150540. View

13.

Hotta A, Ellis J . Retroviral vector silencing during iPS cell induction: an epigenetic beacon that signals distinct pluripotent states. J Cell Biochem. 2008; 105(4):940-8. DOI: 10.1002/jcb.21912. View

14.

Ebert A, Yu J, Rose Jr F, Mattis V, Lorson C, Thomson J . Induced pluripotent stem cells from a spinal muscular atrophy patient. Nature. 2008; 457(7227):277-80. PMC: 2659408. DOI: 10.1038/nature07677. View

15.

West F, Terlouw S, Kwon D, Mumaw J, Dhara S, Hasneen K . Porcine induced pluripotent stem cells produce chimeric offspring. Stem Cells Dev. 2010; 19(8):1211-20. DOI: 10.1089/scd.2009.0458. View

16.

Kunisato A, Wakatsuki M, Kodama Y, Shinba H, Ishida I, Nagao K . Generation of induced pluripotent stem cells by efficient reprogramming of adult bone marrow cells. Stem Cells Dev. 2009; 19(2):229-38. DOI: 10.1089/scd.2009.0149. View

17.

Hargus G, Cooper O, Deleidi M, Levy A, Lee K, Marlow E . Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A. 2010; 107(36):15921-6. PMC: 2936617. DOI: 10.1073/pnas.1010209107. View

18.

Raya A, Rodriguez-Piza I, Guenechea G, Vassena R, Navarro S, Barrero M . Disease-corrected haematopoietic progenitors from Fanconi anaemia induced pluripotent stem cells. Nature. 2009; 460(7251):53-9. PMC: 2720823. DOI: 10.1038/nature08129. View

19.

Shi Y, Desponts C, Do J, Hahm H, Scholer H, Ding S . Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds. Cell Stem Cell. 2008; 3(5):568-74. DOI: 10.1016/j.stem.2008.10.004. View

20.

Takahashi K, Yamanaka S . Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006; 126(4):663-76. DOI: 10.1016/j.cell.2006.07.024. View