Principles and Roles of MRNA Localization in Animal Development

Overview

Journal Development

Specialty Biology

Date 2012 Aug 23

PMID 22912410

Citations 110

Authors

Caroline Medioni

Kimberly Mowry

Florence Besse

Affiliations

Soon will be listed here.

Abstract

Intracellular targeting of mRNAs has long been recognized as a means to produce proteins locally, but has only recently emerged as a prevalent mechanism used by a wide variety of polarized cell types. Localization of mRNA molecules within the cytoplasm provides a basis for cell polarization, thus underlying developmental processes such as asymmetric cell division, cell migration, neuronal maturation and embryonic patterning. In this review, we describe and discuss recent advances in our understanding of both the regulation and functions of RNA localization during animal development.

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