Experience-dependent Regulation of NG2 Progenitors in the Developing Barrel Cortex

Overview

Journal Nat Neurosci

Date 2012 Aug 14

PMID 22885848

Citations 75

Authors

Jean-Marie Mangin

Peijun Li

Joseph Scafidi

Vittorio Gallo

Affiliations

Soon will be listed here.

Abstract

We found that, during the formation of the mouse barrel cortex, NG2 cells received glutamatergic synapses from thalamocortical fibers and preferentially accumulated along septa separating the barrels. Sensory deprivation reduced thalamocortical inputs on NG2 cells and increased their proliferation, leading to a more uniform distribution in the deprived barrels. Thus, early sensory experience regulates thalamocortical innervation on NG2 cells, as well as their proliferation and distribution during development.

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