The Role of Synovitis in Osteoarthritis

Overview

Journal Ther Adv Musculoskelet Dis

Date 2012 Aug 8

PMID 22870460

Citations 54

Authors

Claire Y J Wenham

Philip G Conaghan

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is the most common form of arthritis worldwide yet there is still a lack of effective treatments for this condition. Increasingly, attention has turned to the role of the synovium in OA as it is now recognized, in part from the use of modern imaging techniques, that synovitis is both common and associated with pain. This offers a target for treatment, for both symptom and potential structure modification. In this review we discuss the evidence for histological and imaging-detected synovitis and the current role of antisynovial therapies in OA.

Citing Articles

Statin use and longitudinal bone marrow lesion burden: analysis of knees without osteoarthritis from the Osteoarthritis Initiative study.

Moradi K, Mohajer B, Guermazi A, Hadidchi R, Mohammadi S, Cao X Skeletal Radiol. 2025; .

PMID: 39890641 DOI: 10.1007/s00256-025-04878-6.

Intra-Articular Administration of Ganglioside Sugars Protects Cartilage from Progressive Degeneration in an Instability OA Rabbit Model.

Hamasaki M, Onodera T, Furukawa J, Todoh M, Sakai Y, Ebata T Cartilage. 2025; 19476035241311542.

PMID: 39810328 PMC: 11733871. DOI: 10.1177/19476035241311542.

GAS5 long non-coding RNA interacts with microRNA-205 to relieve fibroblast-like synoviocyte inflammation and ferroptosis in osteoarthritis.

Gu Y, Wang G, Chen P Apoptosis. 2024; 30(1-2):320-333.

PMID: 39644356 DOI: 10.1007/s10495-024-02051-3.

Innate Immunity and Synovitis: Key Players in Osteoarthritis Progression.

Panichi V, Costantini S, Grasso M, Arciola C, Dolzani P Int J Mol Sci. 2024; 25(22).

PMID: 39596150 PMC: 11594236. DOI: 10.3390/ijms252212082.

Obesity-induced fibrosis in osteoarthritis: Pathogenesis, consequences and novel therapeutic opportunities.

Henriques J, Berenbaum F, Mobasheri A Osteoarthr Cartil Open. 2024; 6(4):100511.

PMID: 39483440 PMC: 11525450. DOI: 10.1016/j.ocarto.2024.100511.

References

Haywood L, McWilliams D, Pearson C, Gill S, Ganesan A, Wilson D . Inflammation and angiogenesis in osteoarthritis. Arthritis Rheum. 2003; 48(8):2173-7. DOI: 10.1002/art.11094. View

Lambert R, Hutchings E, Grace M, Jhangri G, Conner-Spady B, Maksymowych W . Steroid injection for osteoarthritis of the hip: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2007; 56(7):2278-87. DOI: 10.1002/art.22739. View

Qvistgaard E, Torp-Pedersen S, Christensen R, Bliddal H . Reproducibility and inter-reader agreement of a scoring system for ultrasound evaluation of hip osteoarthritis. Ann Rheum Dis. 2006; 65(12):1613-9. PMC: 1798465. DOI: 10.1136/ard.2005.050690. View

Keen H, Wakefield R, Grainger A, Hensor E, Emery P, Conaghan P . An ultrasonographic study of osteoarthritis of the hand: synovitis and its relationship to structural pathology and symptoms. Arthritis Rheum. 2008; 59(12):1756-63. DOI: 10.1002/art.24312. View

Goldring M . Anticytokine therapy for osteoarthritis. Expert Opin Biol Ther. 2001; 1(5):817-29. DOI: 10.1517/14712598.1.5.817. View

Sakkas L, Platsoucas C . The role of T cells in the pathogenesis of osteoarthritis. Arthritis Rheum. 2007; 56(2):409-24. DOI: 10.1002/art.22369. View

Murphy L, Schwartz T, Helmick C, Renner J, Tudor G, Koch G . Lifetime risk of symptomatic knee osteoarthritis. Arthritis Rheum. 2008; 59(9):1207-13. PMC: 4516049. DOI: 10.1002/art.24021. View

Dieppe P . Are intra-articular steroid injections useful for the treatment of the osteoarthritis joint?. Br J Rheumatol. 1991; 30(3):199. DOI: 10.1093/rheumatology/30.3.199. View

Bellamy N, Campbell J, Robinson V, Gee T, Bourne R, Wells G . Intraarticular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev. 2006; (2):CD005328. DOI: 10.1002/14651858.CD005328.pub2. View

10.

Loeuille D, Rat A, Goebel J, Champigneulle J, Blum A, Netter P . Magnetic resonance imaging in osteoarthritis: which method best reflects synovial membrane inflammation? Correlations with clinical, macroscopic and microscopic features. Osteoarthritis Cartilage. 2009; 17(9):1186-92. DOI: 10.1016/j.joca.2009.03.006. View

11.

Qvistgaard E, Christensen R, Torp-Pedersen S, Bliddal H . Intra-articular treatment of hip osteoarthritis: a randomized trial of hyaluronic acid, corticosteroid, and isotonic saline. Osteoarthritis Cartilage. 2005; 14(2):163-70. DOI: 10.1016/j.joca.2005.09.007. View

12.

DAgostino M, Conaghan P, Le Bars M, Baron G, Grassi W, Martin-Mola E . EULAR report on the use of ultrasonography in painful knee osteoarthritis. Part 1: prevalence of inflammation in osteoarthritis. Ann Rheum Dis. 2005; 64(12):1703-9. PMC: 1755310. DOI: 10.1136/ard.2005.037994. View

13.

Zhang W, Moskowitz R, Nuki G, Abramson S, Altman R, Arden N . OARSI recommendations for the management of hip and knee osteoarthritis, Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthritis Cartilage. 2008; 16(2):137-62. DOI: 10.1016/j.joca.2007.12.013. View

14.

Smith M, Triantafillou S, Parker A, Youssef P, Coleman M . Synovial membrane inflammation and cytokine production in patients with early osteoarthritis. J Rheumatol. 1997; 24(2):365-71. View

15.

Magnano M, Chakravarty E, Broudy C, Chung L, Kelman A, Hillygus J . A pilot study of tumor necrosis factor inhibition in erosive/inflammatory osteoarthritis of the hands. J Rheumatol. 2007; 34(6):1323-7. View

16.

Kumm J, Tamm A, Lintrop M, Tamm A . Association between ultrasonographic findings and bone/cartilage biomarkers in patients with early-stage knee osteoarthritis. Calcif Tissue Int. 2009; 85(6):514-22. DOI: 10.1007/s00223-009-9302-2. View

17.

Gossec L, Dougados M . Intra-articular treatments in osteoarthritis: from the symptomatic to the structure modifying. Ann Rheum Dis. 2004; 63(5):478-82. PMC: 1755011. DOI: 10.1136/ard.2003.013771. View

18.

Keen H, Lavie F, Wakefield R, DAgostino M, Hammer H, Hensor E . The development of a preliminary ultrasonographic scoring system for features of hand osteoarthritis. Ann Rheum Dis. 2007; 67(5):651-5. DOI: 10.1136/ard.2007.077081. View

19.

Sharif M, Shepstone L, Elson C, Dieppe P, Kirwan J . Increased serum C reactive protein may reflect events that precede radiographic progression in osteoarthritis of the knee. Ann Rheum Dis. 2000; 59(1):71-4. PMC: 1752992. DOI: 10.1136/ard.59.1.71. View

20.

Fernandez-Madrid F, Karvonen R, Teitge R, Miller P, Negendank W . MR features of osteoarthritis of the knee. Magn Reson Imaging. 1994; 12(5):703-9. DOI: 10.1016/0730-725x(94)92194-6. View