The Clinical Meaning of Benign Colon Uptake in (18)F-FDG PET: Comparison with Colonoscopic Findings

Overview

Journal Clin Endosc

Date 2012 Aug 7

PMID 22866255

Citations 9

Authors

Sun Hee Roh

Sung-Ae Jung

Seong-Eun Kim

Hye-In Kim

Min Jin Lee

Chung Hyun Tae

Ju Young Choi

Ki-Nam Shim

Hye-Kyung Jung

Tae Hun Kim

Kwon Yoo

Il Hwan Moon

Bom Sahn Kim

Affiliations

Soon will be listed here.

Abstract

Background/aims: Benign colon (18)F-fluorodeoxyglucose (FDG) uptake is frequently observed in asymptomatic individuals. Aims of this study were to investigate the benign colon uptake by whole body FDG-positron emission tomography (PET) in asymptomatic adults and to correlate those results with colonoscopic and histologic findings.

Methods: Among 3,540 subjects who had undergone FDG-PET, 43 subjects who were diagnosed to have benign colon uptake in FDG-PET and underwent colonoscopy were retrospectively reviewed. Subjects were classified as diffuse or focal groups based on their FDG uptake patterns. PET results were analyzed together with colonoscopic and histologic findings.

Results: Forty-three subjects showed benign colon uptake in FDG-PET; 28 of them were shown as the diffuse group, while other 15 subjects were classified as the focal group. Five subjects among those showed diffuse uptake were diagnosed as adenoma. Seven among 15 subjects who showed focal uptake were diagnosed as adenocarcinoma (n=2), adenoma (n=3), or non-neoplastic polyp (n=2). Positive predictive values were 25% in the diffuse group and 47% in the focal group.

Conclusions: We recommend that patients showing benign FDG uptake in the colon should be further evaluated by colonoscopy, especially for patients with focal FDG uptake.

Citing Articles

Combined SUVmax and localized colonic wall thickening parameters to identify high-risk lesions from incidental focal colorectal F-FDG uptake foci.

Xu W, Li H, Guo Z, Zhang L, Zhang R, Zhang L Front Oncol. 2022; 12:972096.

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Assessment of incidental focal colorectal uptake by analysis of fluorine-18 fluorodeoxyglucose positron emission tomography parameters.

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Kousgaard S, Thorlacius-Ussing O Tech Coloproctol. 2017; 21(7):521-529.

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