Molecular Characterization and Phylogenetic Analysis of Dengue Viruses Imported into Taiwan During 2008-2010

Overview

Journal Am J Trop Med Hyg

Specialty Tropical Medicine

Date 2012 Aug 3

PMID 22855770

Citations 38

Authors

Jyh-Hsiung Huang

Chien-Ling Su

Cheng-Fen Yang

Tsai-Ling Liao

Tung-Chien Hsu

Shu-Fen Chang

Chien-Chou Lin

Pei-Yun Shu

Affiliations

Soon will be listed here.

Abstract

We present our surveillance results on imported dengue cases in Taiwan during 2008-2010. A total of 734 imported dengue patients were identified. The travelers were arriving from 18 countries, including Southeast Asia, the Indian subcontinent, South Pacific islands, and Latin America. Gene sequences from 358 dengue virus (DENV) isolates were used to perform phylogenetic analyses, thus, providing an updated view of the geographic distribution and dynamic transmission of DENV strains circulating in these countries. Our results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant DENV strains circulating in Southeast Asian countries. The DENV-3 Genotype III strain was found to be newly emerging in several Southeast Asian countries, however, the Asian genotype 2 and the Asian/American genotype of DENV-2 strains appeared to be less prevalent in Southeast Asia. Furthermore, imported dengue viruses are representative of the overall patterns of serotype/genotype frequencies of dengue outbreaks that occurred in Taiwan.

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