Evaluation of the Pharmacological Function of Ulinastatin in Experimental Animals

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2012 Aug 2

PMID 22850323

Citations 6

Authors

Chong-En Xu

Meng-Yuan Zhang

Cheng-Wei Zou

Ling Guo

Affiliations

Soon will be listed here.

Abstract

Organ protection is a routine therapy in severe injuries. Our aim was to evaluate the beneficial effects of ulinastatin in experimental rats. Rats were randomly divided into a sham control, a model control and an ulinastatin-treated group. Malondialdehyde (MDA) and superoxide dismutase (SOD) levels were determined. Serum amylase, serum aspartate aminotransaminase (AST), lactate dehydrogenase (LDH) and creatine kinase isoenzyme (CKMD) activities, interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α), nitric oxide (NO) and cardiac troponin I (nTnl) levels were examined. Results showed that ulinastatin decreased MDA levels and ameliorated the down-regulation of SOD activity. In addition, ulinastatin pretreatment may decrease serum AST, LDH and CKMD activities, IL-8, TNF-α, and nTnl levels, and enhance NO level. Our results demonstrated that oxidative injury occurred after IR and that ulinastatin exhibits significant protective effects against these effects.

Citing Articles

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Cryptdin-2 predicts intestinal injury during heatstroke in mice.

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Ulinastatin inhibits oxidant-induced endothelial hyperpermeability and apoptotic signaling.

Li G, Li T, Cai S, Zhang Z, Zeng Z, Wang X Int J Clin Exp Pathol. 2015; 7(11):7342-50.

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