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Meng-Yuan Zhang

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Articles 52
Citations 319
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Recent Articles
1.
Zhang R, Wang Z, Zhang M, Wang Y, Zhou S, Xu J, et al.
J Med Chem . 2025 Feb; 68(5):5075-5096. PMID: 39999563
Mucosa-associated lymphoid tissue protein 1 (MALT1), a cysteine protease and the sole paracaspase in humans, plays a pivotal role in the survival and proliferation of NF-κB-dependent malignant cancers, particularly MALT...
2.
Wang M, Zhang M, Zhao C
Org Lett . 2025 Feb; 27(8):1823-1828. PMID: 39973330
We here disclose synthesis and properties of a series of BN-heterocycle-fused [6]helicenes. The fusion of the BN-heterocycle is helpful to extend π-conjugation and increase absorptivity and fluorescence efficiency of the...
3.
Zhang M, Dong L, Wen Y, Deng J, Cai J
J Food Sci . 2025 Feb; 90(2):e70034. PMID: 39961792
Pectin-derived oligosaccharides, an important source of the new generation of prebiotics, have aroused widespread research. As per our previous study report, the rhamnogalacturonan-I (RG-I) type pectin of dragon fruit positively...
4.
Zhang M, Zhang Y, Yu S, Qiao N, Ni X, Liu Q, et al.
Biomed Chromatogr . 2025 Feb; 39(3):e70022. PMID: 39935377
Danatinib, a brand-new compound synthesized in our laboratory for the treatment of acute myeloid leukemia (AML), demonstrates remarkable antitumor activity. However, the pharmacokinetic profile of Danatinib in mice was short...
5.
Yang J, Zhang Y, Li Y, Wang Q, Zhang M, Xu Y, et al.
Drug Dev Res . 2024 Nov; 85(8):e70022. PMID: 39569546
The abnormal overexpression of FLT3 kinase is intimately associated with pathogenesis of acute myeloid leukemia (AML), positioning FLT3 inhibitors as pivotal therapeutic agents. Despite the availability of three FDA-approved FLT3...
6.
Wei T, Wang Z, Lu M, Xu Y, Yang J, Ni X, et al.
J Med Chem . 2024 Sep; 67(24):21752-21780. PMID: 39258312
The FLT3-ITD (internal tandem duplication) mutant has been a promising target for acute myeloid leukemia (AML) drug discovery but is now facing the challenge of resistance due to point mutations....
7.
Zhang M, Wei T, Han C, Tan C, Xie T, Cai J, et al.
Environ Pollut . 2024 Aug; 360:124764. PMID: 39154884
Cigarette smoke (CS) is an important indoor air pollutant associated with an increased risk of ocular surface disease. As the eye's outermost layer, the cornea is highly sensitive to air...
8.
Zhang N, Han M, Zheng Q, Zhang M, Zhi W, Li J, et al.
Front Pharmacol . 2024 Aug; 15:1393526. PMID: 39139634
Background: Refractory gastroesophageal reflux disease (refractory GERD) is a heterogeneous disease characterized by unresponsiveness or poor efficacy to proton-pump inhibitors (PPIs). This chronic disorder substantially weakens patients' mental wellbeing and...
9.
Wang Q, Cai J, Chen Z, Liu J, Wang J, Zhou H, et al.
Mol Inform . 2024 Jul; 43(9):e202300336. PMID: 39031899
Kinases, a class of enzymes controlling various substrates phosphorylation, are pivotal in both physiological and pathological processes. Although their conserved ATP binding pockets pose challenges for achieving selectivity, this feature...
10.
Zhang Z, Shang Y, Zhang M, Zhang J, Geng Y, Xia J, et al.
MycoKeys . 2024 Jul; 106:303-325. PMID: 38993357
Species of the family Microdochiaceae (Xylariales, Sordariomycetes) have been reported from worldwide, and collected from different plant hosts. The proposed new genus and two new species, , , and ,...