Control of Innate and Adaptive Immunity by the Inflammasome

Overview

Journal Microbes Infect

Publisher Elsevier

Specialties Allergy & Immunology
Microbiology

Date 2012 Jul 31

PMID 22841804

Citations 42

Authors

Ceren Ciraci

John R Janczy

Fayyaz S Sutterwala

Suzanne L Cassel

Affiliations

Soon will be listed here.

Abstract

The importance of innate immunity lies not only in directly confronting pathogenic and non-pathogenic insults but also in instructing the development of an efficient adaptive immune response. The Nlrp3 inflammasome provides a platform for the activation of caspase-1 with the subsequent processing and secretion of IL-1 family members. Given the importance of IL-1 in a variety of inflammatory diseases, understanding the role of the Nlrp3 inflammasome in the initiation of innate and adaptive immune responses cannot be overstated. This review examines recent advances in inflammasome biology with an emphasis on its roles in sterile inflammation and triggering of adaptive immune responses.

Citing Articles

NLRP3 Inflammasome in the Pathogenesis of Miscarriages.

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Daidzein and Equol: Ex Vivo and In Silico Approaches Targeting COX-2, iNOS, and the Canonical Inflammasome Signaling Pathway.

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IgE Immune Complexes Mitigate Eosinophilic Immune Responses through NLRC4 Inflammasome.

Oylumlu E, Uzel G, Durmus L, Ciraci C Mediators Inflamm. 2023; 2023:3224708.

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