C1q/TNF-related Protein-3 (CTRP-3) and Pigment Epithelium-derived Factor (PEDF) Concentrations in Patients with Type 2 Diabetes and Metabolic Syndrome

Overview

Journal Diabetes

Specialty Endocrinology

Date 2012 Jul 28

PMID 22837306

Citations 56

Authors

Kyung Mook Choi

Soon Young Hwang

Ho Cheol Hong

Sae Jeong Yang

Hae Yoon Choi

Hye Jin Yoo

Kwan Woo Lee

Moon Suk Nam

Yong Soo Park

Jeong Taek Woo

Young Seol Kim

Dong Seop Choi

Byung-Soo Youn

Sei Hyun Baik

Affiliations

Soon will be listed here.

Abstract

Recent studies have suggested that a novel adipokine, C1q/tumor necrosis factor-related protein-3 (CTRP-3), a paralog of adiponectin, may play an important role in the regulation of glucose metabolism and innate immunity. Pigment epithelium-derived factor (PEDF), a multifunctional protein with antioxidant and anti-inflammatory properties, is associated with insulin resistance and metabolic syndrome. We examined circulating CTRP-3 and PEDF concentrations in 345 subjects with diverse glucose tolerance statuses. Furthermore, we evaluated the involvement of CTRP-3 and PEDF with cardiometabolic risk factors including insulin resistance, high-sensitivity C-reactive protein (hsCRP), estimated glomerular filtration rate (eGFR), and brachial-ankle pulse wave velocity (baPWV). CTRP-3 concentrations were significantly higher in patients with type 2 diabetes or prediabetes than the normal glucose tolerance group, whereas PEDF levels were not different. Subjects with metabolic syndrome showed significantly higher levels of both CTRP-3 and PEDF compared with subjects without metabolic syndrome. Both CTRP-3 and PEDF were significantly associated with cardiometabolic parameters, including waist-to-hip ratio, triglycerides, HDL-cholesterol, alanine aminotransferase, eGFR, hsCRP, and baPWV. In conclusion, circulating CTRP-3 concentrations were elevated in patients with glucose metabolism dysregulation. Both CTRP-3 and PEDF concentrations were increased in subjects with metabolic syndrome and associated with various cardiometabolic risk factors.

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