New Insights Into Implications of CTRP3 in Obesity, Metabolic Dysfunction, and Cardiovascular Diseases: Potential of Therapeutic Interventions

Overview

Journal Front Physiol

Date 2020 Dec 21

PMID 33343381

Citations 9

Authors

Bei Guo

Tongtian Zhuang

Feng Xu

Xiao Lin

Fuxingzi Li

Su-Kang Shan

Feng Wu

Jia-Yu Zhong

Yi Wang

Ming-Hui Zheng

Qiu-Shuang Xu

Ullah Muhammad Hasnain Ehsan

Ling-Qing Yuan

Affiliations

Soon will be listed here.

Abstract

Adipose tissue, as the largest endocrine organ, secretes many biologically active molecules circulating in the bloodstream, collectively termed adipocytokines, which not only regulate the metabolism but also play a role in pathophysiological processes. C1q tumor necrosis factor (TNF)-related protein 3 (CTRP3) is a member of C1q tumor necrosis factor-related proteins (CTRPs), which is a paralog of adiponectin. CTRP3 has a wide range of effects on glucose/lipid metabolism, inflammation, and contributes to cardiovascular protection. In this review, we comprehensively discussed the latest research on CTRP3 in obesity, diabetes, metabolic syndrome, and cardiovascular diseases.

Citing Articles

Mechanism of KDM4A in Regulating Microglial Polarization in Ischemic Stroke.

Du J, Liang X, Wang D, Wang Z, Shen R Appl Biochem Biotechnol. 2025; .

PMID: 40080374 DOI: 10.1007/s12010-025-05207-2.

Decreased Serum CTRP3 level was associated with connective tissue diseases.

Ma L, Lin J, Shao M, Chen B, Zhou R, Shi J Heliyon. 2024; 10(16):e36322.

PMID: 39253249 PMC: 11382063. DOI: 10.1016/j.heliyon.2024.e36322.

Relation between serum sclerostin and CTRP3 levels and bone mineral density in diabetic postmenopausal women.

Ahmad I, Elhamed Gbr S, Ali El Naggar B, Abdelwahab M, El-Saghier E, Sayed Mohammed D BMC Womens Health. 2024; 24(1):490.

PMID: 39237913 PMC: 11375883. DOI: 10.1186/s12905-024-03311-9.

Effects of silymarin as adjuvant drug on serum levels of CTRP3, anti-cyclic citrullinated peptide (CCP), and high-sensitivity C-reactive protein (hs-CRP) in rheumatoid arthritis patients.

Elahi M, Elieh-Ali-Komi D, Goudarzi F, Mohammadi Noori E, Assar S, Shavandi M Mol Biol Res Commun. 2024; 13(3):137-145.

PMID: 38915456 PMC: 11194032. DOI: 10.22099/mbrc.2024.48466.1876.

Decreased circulating CTRP3 levels in acute and chronic cardiovascular patients.

Schmid A, Pankuweit S, Vlacil A, Koch S, Berge B, Gajawada P J Mol Med (Berl). 2024; 102(5):667-677.

PMID: 38436713 PMC: 11055757. DOI: 10.1007/s00109-024-02426-8.

References

Song Y, Mai H, Lin Y, Wang Y, Wang X, Gu S . MiR-144 affects proliferation and apoptosis of high glucose-induced AC16 cardiomyocytes by regulating CTRP3/JNK signaling. Int J Clin Exp Pathol. 2020; 13(2):142-152. PMC: 7061800. View

Cho N, Shaw J, Karuranga S, Huang Y, da Rocha Fernandes J, Ohlrogge A . IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045. Diabetes Res Clin Pract. 2018; 138:271-281. DOI: 10.1016/j.diabres.2018.02.023. View

Zhang B, Zhang P, Tan Y, Feng P, Zhang Z, Liang H . C1q-TNF-related protein-3 attenuates pressure overload-induced cardiac hypertrophy by suppressing the p38/CREB pathway and p38-induced ER stress. Cell Death Dis. 2019; 10(7):520. PMC: 6614451. DOI: 10.1038/s41419-019-1749-0. View

Donath M, Shoelson S . Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011; 11(2):98-107. DOI: 10.1038/nri2925. View

Zhang J, Zhang B, Cheng Y, Xu J . Low serum CTRP3 levels are associated with nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus. Cytokine. 2017; 106:131-135. DOI: 10.1016/j.cyto.2017.10.023. View

Akoumianakis I, Antoniades C . The interplay between adipose tissue and the cardiovascular system: is fat always bad?. Cardiovasc Res. 2017; 113(9):999-1008. DOI: 10.1093/cvr/cvx111. View

Liu M, Xiang R, Wilk S, Zhang N, Sloane L, Azarnoush K . Fat-specific DsbA-L overexpression promotes adiponectin multimerization and protects mice from diet-induced obesity and insulin resistance. Diabetes. 2012; 61(11):2776-86. PMC: 3478538. DOI: 10.2337/db12-0169. View

Maeda T, Abe M, Kurisu K, Jikko A, Furukawa S . Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development. J Biol Chem. 2000; 276(5):3628-34. DOI: 10.1074/jbc.M007898200. View

Nishimoto H, Yamamoto A, Furukawa S, Wakisaka S, Maeda T . C1q/TNF-related protein 3 expression and effects on adipocyte differentiation of 3T3-L1 cells. Cell Biol Int. 2016; 41(2):197-203. DOI: 10.1002/cbin.10674. View

10.

Otani M, Kogo M, Furukawa S, Wakisaka S, Maeda T . The adiponectin paralog C1q/TNF-related protein 3 (CTRP3) stimulates testosterone production through the cAMP/PKA signaling pathway. Cytokine. 2012; 58(2):238-44. DOI: 10.1016/j.cyto.2012.01.018. View

11.

Kopp A, Bala M, Buechler C, Falk W, Gross P, Neumeier M . C1q/TNF-related protein-3 represents a novel and endogenous lipopolysaccharide antagonist of the adipose tissue. Endocrinology. 2010; 151(11):5267-78. DOI: 10.1210/en.2010-0571. View

12.

Lei X, Li Q, Rodriguez S, Tan S, Seldin M, McLenithan J . Thromboxane synthase deficiency improves insulin action and attenuates adipose tissue fibrosis. Am J Physiol Endocrinol Metab. 2015; 308(9):E792-804. PMC: 4420899. DOI: 10.1152/ajpendo.00383.2014. View

13.

Yang B, Wang S, Yu S, Chen Y, Li L, Zhang H . C1q/tumor necrosis factor-related protein 3 inhibits oxidative stress during intracerebral hemorrhage via PKA signaling. Brain Res. 2016; 1657:176-184. DOI: 10.1016/j.brainres.2016.11.016. View

14.

Zheng Q, Yuan Y, Yi W, Lau W, Wang Y, Wang X . C1q/TNF-related proteins, a family of novel adipokines, induce vascular relaxation through the adiponectin receptor-1/AMPK/eNOS/nitric oxide signaling pathway. Arterioscler Thromb Vasc Biol. 2011; 31(11):2616-23. PMC: 3197867. DOI: 10.1161/ATVBAHA.111.231050. View

15.

Rehorst W, Thelen M, Nolte H, Turk C, Cirak S, Peterson J . Muscle regulates mTOR dependent axonal local translation in motor neurons via CTRP3 secretion: implications for a neuromuscular disorder, spinal muscular atrophy. Acta Neuropathol Commun. 2019; 7(1):154. PMC: 6794869. DOI: 10.1186/s40478-019-0806-3. View

16.

Schaffler A, Weigert J, Neumeier M, Scholmerich J, Buechler C . Regulation and function of collagenous repeat containing sequence of 26-kDa protein gene product "cartonectin". Obesity (Silver Spring). 2007; 15(2):303-13. DOI: 10.1038/oby.2007.566. View

17.

Li X, Jiang L, Yang M, Wu Y, Sun S, Sun J . GLP-1 receptor agonist increases the expression of CTRP3, a novel adipokine, in 3T3-L1 adipocytes through PKA signal pathway. J Endocrinol Invest. 2014; 38(1):73-9. DOI: 10.1007/s40618-014-0156-8. View

18.

Moradi N, Fadaei R, Khamseh M, Nobakht A, Rezaei M, Aliakbary F . Serum levels of CTRP3 in diabetic nephropathy and its relationship with insulin resistance and kidney function. PLoS One. 2019; 14(4):e0215617. PMC: 6476508. DOI: 10.1371/journal.pone.0215617. View

19.

Liu M, Zhou L, Xu A, Lam K, Wetzel M, Xiang R . A disulfide-bond A oxidoreductase-like protein (DsbA-L) regulates adiponectin multimerization. Proc Natl Acad Sci U S A. 2008; 105(47):18302-7. PMC: 2587637. DOI: 10.1073/pnas.0806341105. View

20.

Schaffler A, Ehling A, Neumann E, Herfarth H, Tarner I, Gay S . Genomic organization, chromosomal localization and adipocytic expression of the murine gene for CORS-26 (collagenous repeat-containing sequence of 26 kDa protein). Biochim Biophys Acta. 2003; 1628(1):64-70. DOI: 10.1016/s0167-4781(03)00114-3. View