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» Articles » PMID: 22828655

That the Effects of Smoking Should Be Measured in Pack-years: Misconceptions 4

Overview
Journal Br J Cancer
Specialty Oncology
Date 2012 Jul 26
PMID 22828655
Citations 48
Authors
J Peto
Affiliations
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Abstract

Lung cancer incidence in smokers is roughly proportional to dose rate (cigarettes per day) but increases much more rapidly with duration of smoking. The assumption that the incidence rate is proportional to total lifetime dose (the product of dose rate and duration) has been known to be wrong for many years, but total dose in pack-years is still often included, either alone or together, with more fundamental parameters such as dose rate, in regression analysis of epidemiological data. This is mathematically unnecessary and scientifically unhelpful.

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