Requirement of Signal Peptidase ComC and Thiol-disulfide Oxidoreductase DsbA for Optimal Cell Surface Display of Pseudopilin ComGC in Staphylococcus Aureus

Overview

Journal Appl Environ Microbiol

Specialties Environmental Health
Microbiology

Date 2012 Jul 24

PMID 22820325

Citations 8

Authors

Magdalena M van der Kooi-Pol

Ewoud Reilman

Mark J J B Sibbald

Yanka K Veenstra-Kyuchukova

Thijs R H M Kouwen

Girbe Buist

Jan Maarten van Dijl

Affiliations

Soon will be listed here.

Abstract

Staphylococcus aureus is an important Gram-positive bacterial pathogen producing many secreted and cell surface-localized virulence factors. Here we report that the staphylococcal thiol-disulfide oxidoreductase DsbA is essential for stable biogenesis of the ComGC pseudopilin. The signal peptidase ComC is indispensable for ComGC maturation and optimal cell surface exposure.

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