Oesophageal Squamous Cell Carcinoma: Relationship Between Fluorine-18 Fludeoxyglucose Positron Emission Tomography CT Maximum Standardised Uptake Value, Metabolic Tumour Volume, and Tumour, Node and Metastasis Classification

Overview

Journal Br J Radiol

Publisher Oxford University Press

Specialty Radiology

Date 2012 Jul 21

PMID 22815420

Citations 6

Authors

W-Q Zhu

L Xing

M Li

J Yue

W Qu

X Sun

L Kong

J Yu

Affiliations

Soon will be listed here.

Abstract

Objectives: We aimed to evaluate the relationships between primary tumour, maximum standardised uptake value, metabolic tumour volume and seventh edition American Joint Committee on Cancer (AJCC) classification in oesophageal squamous cell carcinoma (OSCC) patients.

Methods: Fluorine-18 fludeoxyglucose ((18)F-FDG) positron emission tomography (PET)-CT scans of 41 consecutive newly diagnosed OSCC patients were retrospectively reviewed. Maximum standard uptake value (SUV(max)) and metabolic tumour volume (MTV) were recorded. Two-tailed Spearman's correlation was used to analyse the relationships between the metabolic parameters and the AJCC staging system.

Results: Positive correlations were observed between SUV(max), MTV and tumour (T) stage, in addition to node (N) stage and AJCC stage. Both metabolic parameters were independent variables that significantly affected the N stage and AJCC stage, and SUV(max) was the only independent variable that significantly affected the T stage.

Conclusion: The metabolic parameters derived from (18)F-FDG PET-CT were positively correlated with T, N and AJCC stage in primary OSCC. Our findings may suggest a complementary role of these parameters to seventh-edition AJCC staging in the prognostication of OSCC patients.

Citing Articles

FDG PET/CT and Endoscopic Ultrasound for Preoperative T-Staging of Esophageal Squamous Cell Carcinoma.

Huang Y, Chiu N, Lu H, Chiu Y, Hsu C, Wang Y Diagnostics (Basel). 2023; 13(19).

PMID: 37835827 PMC: 10572619. DOI: 10.3390/diagnostics13193083.

Intratumoral Metabolic Heterogeneity and Other Quantitative F-FDG PET/CT Parameters for Prognosis Prediction in Esophageal Cancer.

Gopal A, Xi Y, Subramaniam R, Pinho D Radiol Imaging Cancer. 2021; 3(1):e200022.

PMID: 33778756 PMC: 7983774. DOI: 10.1148/rycan.2020200022.

Queuine Micronutrient Deficiency Promotes Warburg Metabolism and Reversal of the Mitochondrial ATP Synthase in Hela Cells.

Hayes P, Fergus C, Ghanim M, Cirzi C, Burtnyak L, McGrenaghan C Nutrients. 2020; 12(3).

PMID: 32213952 PMC: 7146442. DOI: 10.3390/nu12030871.

FDG PET using SUV for preoperative T-staging of esophageal squamous cell carcinoma with and without neoadjuvant chemoradiotherapy.

Huang Y, Lu H, Huang S, Hsu C, Chiu N, Wang Y BMC Med Imaging. 2017; 17(1):1.

PMID: 28056868 PMC: 5217536. DOI: 10.1186/s12880-016-0171-7.

Pre-Chemoradiotherapy FDG PET/CT cannot Identify Residual Metabolically-Active Volumes within Individual Esophageal Tumors.

Lu W, Tan S, Chen W, Kligerman S, Feigenberg S, Zhang H J Nucl Med Radiat Ther. 2015; 6(3).

PMID: 26594591 PMC: 4652953. DOI: 10.4172/2155-9619.1000226.

References

Chua D, Sham J, Leung L, Tai K, Au G . Tumor volume is not an independent prognostic factor in early-stage nasopharyngeal carcinoma treated by radiotherapy alone. Int J Radiat Oncol Biol Phys. 2004; 58(5):1437-44. DOI: 10.1016/j.ijrobp.2003.09.075. View

Zhu W, Yu J, Sun X, Xie P, Kong L . Serum CYFRA21-1 as a prognostic marker for patients with undifferentiated nasopharyngeal carcinoma. Biomarkers. 2010; 15(7):602-7. DOI: 10.3109/1354750X.2010.504309. View

Hu Y, Hu C, Zhang H, Ping Y, Chen L . How does the number of resected lymph nodes influence TNM staging and prognosis for esophageal carcinoma?. Ann Surg Oncol. 2009; 17(3):784-90. DOI: 10.1245/s10434-009-0818-5. View

Miller T, Grigsby P . Measurement of tumor volume by PET to evaluate prognosis in patients with advanced cervical cancer treated by radiation therapy. Int J Radiat Oncol Biol Phys. 2002; 53(2):353-9. DOI: 10.1016/s0360-3016(02)02705-0. View

Lee P, Weerasuriya D, Lavori P, Quon A, Hara W, Maxim P . Metabolic tumor burden predicts for disease progression and death in lung cancer. Int J Radiat Oncol Biol Phys. 2007; 69(2):328-33. DOI: 10.1016/j.ijrobp.2007.04.036. View

Allal A, Dulguerov P, Allaoua M, Haenggeli C, Lehmann W, Slosman D . Standardized uptake value of 2-[(18)F] fluoro-2-deoxy-D-glucose in predicting outcome in head and neck carcinomas treated by radiotherapy with or without chemotherapy. J Clin Oncol. 2002; 20(5):1398-404. DOI: 10.1200/JCO.2002.20.5.1398. View

Choi J, Lee K, Shim Y, Lee K, Kim J, Kim S . Improved detection of individual nodal involvement in squamous cell carcinoma of the esophagus by FDG PET. J Nucl Med. 2000; 41(5):808-15. View

Minn H, Lapela M, Klemi P, Grenman R, Leskinen S, Lindholm P . Prediction of survival with fluorine-18-fluoro-deoxyglucose and PET in head and neck cancer. J Nucl Med. 1998; 38(12):1907-11. View

Kelly S, Harris K, Berry E, Hutton J, Roderick P, Cullingworth J . A systematic review of the staging performance of endoscopic ultrasound in gastro-oesophageal carcinoma. Gut. 2001; 49(4):534-9. PMC: 1728456. DOI: 10.1136/gut.49.4.534. View

10.

Greco C, Rosenzweig K, Cascini G, Tamburrini O . Current status of PET/CT for tumour volume definition in radiotherapy treatment planning for non-small cell lung cancer (NSCLC). Lung Cancer. 2007; 57(2):125-34. DOI: 10.1016/j.lungcan.2007.03.020. View

11.

Crippa F, Agresti R, Seregni E, Greco M, Pascali C, Bogni A . Prospective evaluation of fluorine-18-FDG PET in presurgical staging of the axilla in breast cancer. J Nucl Med. 1998; 39(1):4-8. View

12.

Chen Y, Schultheiss T, Wong J, Kernstine K . Impact of the number of resected and involved lymph nodes on esophageal cancer survival. J Surg Oncol. 2009; 100(2):127-32. DOI: 10.1002/jso.21312. View

13.

Kitagawa Y, Sano K, Nishizawa S, Nakamura M, Ogasawara T, Sadato N . FDG-PET for prediction of tumour aggressiveness and response to intra-arterial chemotherapy and radiotherapy in head and neck cancer. Eur J Nucl Med Mol Imaging. 2002; 30(1):63-71. DOI: 10.1007/s00259-002-0978-z. View

14.

Ball D, Fisher R, Burmeister B, Graham P, Joseph D, Penniment M . Stage is not a reliable indicator of tumor volume in non-small cell lung cancer: a preliminary analysis of the Trans-Tasman Radiation Oncology Group 99-05 database. J Thorac Oncol. 2007; 1(7):667-72. View

15.

Chung M, Jeong H, Park S, Jang J, Son Y, Choi J . Metabolic tumor volume of [18F]-fluorodeoxyglucose positron emission tomography/computed tomography predicts short-term outcome to radiotherapy with or without chemotherapy in pharyngeal cancer. Clin Cancer Res. 2009; 15(18):5861-8. DOI: 10.1158/1078-0432.CCR-08-3290. View

16.

Chan W, Mak H, Huang B, Yeung D, Kwong D, Khong P . Nasopharyngeal carcinoma: relationship between 18F-FDG PET-CT maximum standardized uptake value, metabolic tumour volume and total lesion glycolysis and TNM classification. Nucl Med Commun. 2009; 31(3):206-10. DOI: 10.1097/MNM.0b013e328333e3ef. View

17.

Davies A, Tan C, Paschalides C, Barrington S, ODoherty M, Utley M . FDG-PET maximum standardised uptake value is associated with variation in survival: analysis of 498 lung cancer patients. Lung Cancer. 2006; 55(1):75-8. DOI: 10.1016/j.lungcan.2006.09.010. View

18.

van Vliet E, Heijenbrok-Kal M, Hunink M, Kuipers E, Siersema P . Staging investigations for oesophageal cancer: a meta-analysis. Br J Cancer. 2008; 98(3):547-57. PMC: 2243147. DOI: 10.1038/sj.bjc.6604200. View

19.

Sasaki R, Komaki R, Macapinlac H, Erasmus J, Allen P, Forster K . [18F]fluorodeoxyglucose uptake by positron emission tomography predicts outcome of non-small-cell lung cancer. J Clin Oncol. 2005; 23(6):1136-43. DOI: 10.1200/JCO.2005.06.129. View

20.

Hunerbein M, Ulmer C, Handke T, Schlag P . Endosonography of upper gastrointestinal tract cancer on demand using miniprobes or endoscopic ultrasound. Surg Endosc. 2003; 17(4):615-9. DOI: 10.1007/s00464-002-8622-3. View