Vitamin D in Sepsis: from Basic Science to Clinical Impact

Overview

Journal Crit Care

Specialty Critical Care

Date 2012 Jul 20

PMID 22809263

Citations 33

Authors

Jordan A Kempker

Vin Tangpricha

Thomas R Ziegler

Greg S Martin

Affiliations

Soon will be listed here.

Abstract

The growing basic and clinical investigations into the extraskeletal effects of vitamin D have revealed roles in the functioning of the immune system, generating interesting questions about this nutrient's connections to sepsis. This article briefly reviews the current science of the function of vitamin D in the immune system as well as the emerging clinical literature regarding its associations with respiratory infections, sepsis, and critical illness. Finally, we offer views on the potential future directions for research in the field by outlining potential relevant scenarios and outcomes.

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References

Sadeghi K, Wessner B, Laggner U, Ploder M, Tamandl D, Friedl J . Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns. Eur J Immunol. 2006; 36(2):361-70. DOI: 10.1002/eji.200425995. View

Roth D, Shah R, Black R, Baqui A . Vitamin D status and acute lower respiratory infection in early childhood in Sylhet, Bangladesh. Acta Paediatr. 2009; 99(3):389-93. DOI: 10.1111/j.1651-2227.2009.01594.x. View

Melamed M, Michos E, Post W, Astor B . 25-hydroxyvitamin D levels and the risk of mortality in the general population. Arch Intern Med. 2008; 168(15):1629-37. PMC: 2677029. DOI: 10.1001/archinte.168.15.1629. View

Nijnik A, Hancock R . The roles of cathelicidin LL-37 in immune defences and novel clinical applications. Curr Opin Hematol. 2008; 16(1):41-7. DOI: 10.1097/moh.0b013e32831ac517. View

Braun A, Gibbons F, Litonjua A, Giovannucci E, Christopher K . Low serum 25-hydroxyvitamin D at critical care initiation is associated with increased mortality. Crit Care Med. 2011; 40(1):63-72. PMC: 4427350. DOI: 10.1097/CCM.0b013e31822d74f3. View

Ginde A, Camargo Jr C, Shapiro N . Vitamin D insufficiency and sepsis severity in emergency department patients with suspected infection. Acad Emerg Med. 2011; 18(5):551-4. DOI: 10.1111/j.1553-2712.2011.01047.x. View

Roth D, Jones A, Prosser C, Robinson J, Vohra S . Vitamin D status is not associated with the risk of hospitalization for acute bronchiolitis in early childhood. Eur J Clin Nutr. 2007; 63(2):297-9. DOI: 10.1038/sj.ejcn.1602946. View

Esper A, Moss M, Lewis C, Nisbet R, Mannino D, Martin G . The role of infection and comorbidity: Factors that influence disparities in sepsis. Crit Care Med. 2006; 34(10):2576-82. PMC: 3926300. DOI: 10.1097/01.CCM.0000239114.50519.0E. View

Amrein K, Venkatesh B . Vitamin D and the critically ill patient. Curr Opin Clin Nutr Metab Care. 2011; 15(2):188-93. DOI: 10.1097/MCO.0b013e32834f0027. View

10.

Equils O, Naiki Y, Shapiro A, Michelsen K, Lu D, Adams J . 1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin Exp Immunol. 2005; 143(1):58-64. PMC: 1809565. DOI: 10.1111/j.1365-2249.2005.02961.x. View

11.

McKinney J, Bailey B, Garrett L, Peiris P, Manning T, Peiris A . Relationship between vitamin D status and ICU outcomes in veterans. J Am Med Dir Assoc. 2011; 12(3):208-11. DOI: 10.1016/j.jamda.2010.04.004. View

12.

Zhao G, Ford E, Li C, Croft J . Serum 25-hydroxyvitamin D levels and all-cause and cardiovascular disease mortality among US adults with hypertension: the NHANES linked mortality study. J Hypertens. 2011; 30(2):284-9. DOI: 10.1097/HJH.0b013e32834e1f0a. View

13.

Manaseki-Holland S, Qader G, Masher M, Bruce J, Mughal M, Chandramohan D . Effects of vitamin D supplementation to children diagnosed with pneumonia in Kabul: a randomised controlled trial. Trop Med Int Health. 2010; 15(10):1148-55. DOI: 10.1111/j.1365-3156.2010.02578.x. View

14.

Zhang Y, Leung D, Richers B, Liu Y, Remigio L, Riches D . Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012; 188(5):2127-35. PMC: 3368346. DOI: 10.4049/jimmunol.1102412. View

15.

Mata-Granados J, Vargas-Vasserot J, Ferreiro-Vera C, Luque de Castro M, Guerrero Pavon R, Quesada Gomez J . Evaluation of vitamin D endocrine system (VDES) status and response to treatment of patients in intensive care units (ICUs) using an on-line SPE-LC-MS/MS method. J Steroid Biochem Mol Biol. 2010; 121(1-2):452-5. DOI: 10.1016/j.jsbmb.2010.03.078. View

16.

Khoo A, Chai L, Koenen H, Kullberg B, Joosten I, van der Ven A . 1,25-dihydroxyvitamin D3 modulates cytokine production induced by Candida albicans: impact of seasonal variation of immune responses. J Infect Dis. 2010; 203(1):122-30. PMC: 3086448. DOI: 10.1093/infdis/jiq008. View

17.

Grant W, Peiris A . Possible role of serum 25-hydroxyvitamin D in black-white health disparities in the United States. J Am Med Dir Assoc. 2010; 11(9):617-28. DOI: 10.1016/j.jamda.2010.03.013. View

18.

Ginde A, Mansbach J, Camargo Jr C . Association between serum 25-hydroxyvitamin D level and upper respiratory tract infection in the Third National Health and Nutrition Examination Survey. Arch Intern Med. 2009; 169(4):384-90. PMC: 3447082. DOI: 10.1001/archinternmed.2008.560. View

19.

Li-Ng M, Aloia J, Pollack S, Cunha B, Mikhail M, Yeh J . A randomized controlled trial of vitamin D3 supplementation for the prevention of symptomatic upper respiratory tract infections. Epidemiol Infect. 2009; 137(10):1396-404. DOI: 10.1017/S0950268809002404. View

20.

Barnato A, Alexander S, Linde-Zwirble W, Angus D . Racial variation in the incidence, care, and outcomes of severe sepsis: analysis of population, patient, and hospital characteristics. Am J Respir Crit Care Med. 2007; 177(3):279-84. PMC: 2720103. DOI: 10.1164/rccm.200703-480OC. View