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Tyrosyl Phosphorylation Toggles a Runx1 Switch

Overview
Journal Genes Dev
Specialty Molecular Biology
Date 2012 Jul 18
PMID 22802526
Citations 4
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Abstract

The Runx1 transcription factor is post-translationally modified by seryl/threonyl phosphorylation, acetylation, and methylation that control its interactions with transcription factor partners and epigenetic coregulators. In this issue of Genes & Development, Huang and colleagues (pp. 1587-1601) describe how the regulation of Runx1 tyrosyl phosphorylation by Src family kinases and the Shp2 phosphatase toggle Runx1's interactions between different coregulatory molecules.

Citing Articles

RUNX1 isoforms regulate RUNX1 and target genes differentially in platelets-megakaryocytes: association with clinical cardiovascular events.

Guan L, Voora D, Myers R, Del Carpio-Cano F, Rao A J Thromb Haemost. 2024; 22(12):3581-3598.

PMID: 39181539 PMC: 11608153. DOI: 10.1016/j.jtha.2024.07.032.


RUNX1 Isoforms Regulate RUNX1 and Target-Genes Differentially in Platelets-Megakaryocytes: Association with Clinical Cardiovascular Events.

Guan L, Voora D, Myers R, Del Carpio-Cano F, Rao A bioRxiv. 2024; .

PMID: 38948740 PMC: 11212995. DOI: 10.1101/2024.06.18.599563.


Charged Amino Acid-rich Leucine Zipper-1 (Crlz-1) as a Target of Wnt Signaling Pathway Controls Pre-B Cell Proliferation by Affecting Runx/CBFβ-targeted VpreB and λ5 Genes.

Choi S, Park S, Yoo H, Pi J, Kang C J Biol Chem. 2016; 291(29):15008-19.

PMID: 27226553 PMC: 4946919. DOI: 10.1074/jbc.M115.712901.


Posttranslational modifications of RUNX1 as potential anticancer targets.

Goyama S, Huang G, Kurokawa M, Mulloy J Oncogene. 2014; 34(27):3483-92.

PMID: 25263451 DOI: 10.1038/onc.2014.305.

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