No Evidence for Inositol 1,4,5-trisphosphate-dependent Ca2+ Release in Isolated Fibers of Adult Mouse Skeletal Muscle

Overview

Journal J Gen Physiol

Specialty Physiology

Date 2012 Jul 18

PMID 22802359

Citations 17

Authors

Bert Blaauw

Paola Del Piccolo

Laura Rodriguez

Victor-Hugo Hernandez Gonzalez

Lisa Agatea

Francesca Solagna

Fabio Mammano

Tullio Pozzan

Stefano Schiaffino

Affiliations

Soon will be listed here.

Abstract

The presence and role of functional inositol 1,4,5-trisphosphate (IP(3)) receptors (IP(3)Rs) in adult skeletal muscle are controversial. The current consensus is that, in adult striated muscle, the relative amount of IP(3)Rs is too low and the kinetics of Ca(2+) release from IP(3)R is too slow compared with ryanodine receptors to contribute to the Ca(2+) transient during excitation-contraction coupling. However, it has been suggested that IP(3)-dependent Ca(2+) release may be involved in signaling cascades leading to regulation of muscle gene expression. We have reinvestigated IP(3)-dependent Ca(2+) release in isolated flexor digitorum brevis (FDB) muscle fibers from adult mice. Although Ca(2+) transients were readily induced in cultured C2C12 muscle cells by (a) UTP stimulation, (b) direct injection of IP(3), or (c) photolysis of membrane-permeant caged IP(3), no statistically significant change in calcium signal was detected in adult FDB fibers. We conclude that the IP(3)-IP(3)R system does not appear to affect global calcium levels in adult mouse skeletal muscle.

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