Innate Neural Stem Cell Heterogeneity Determines the Patterning of Glioma Formation in Children

Overview

Journal Cancer Cell

Publisher Cell Press

Specialty Oncology

Date 2012 Jul 14

PMID 22789544

Citations 69

Authors

Da Yong Lee

Scott M Gianino

David H Gutmann

Affiliations

Soon will be listed here.

Abstract

The concept that gliomas comprise a heterogeneous group of diseases distinguished by their developmental origin raises the intriguing possibility that neural stem cells (NSCs) from different germinal zones have differential capacities to respond to glioma-causing genetic changes. We demonstrate that lateral ventricle subventricular zone NSCs are molecularly and functionally distinct from those of the third ventricle. Consistent with a unique origin for pediatric low-grade glioma, third ventricle, but not lateral ventricle, NSCs hyperproliferate in response to mutations characteristic of childhood glioma. Finally, we demonstrate that pediatric optic gliomas in Nf1 genetically engineered mice arise from the third ventricle. Collectively, these observations establish the importance of innate brain region NSC heterogeneity in the patterning of gliomagenesis in children and adults.

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