Copper-catalyzed Aerobic Aliphatic C-H Oxygenation Directed by an Amidine Moiety

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2012 Jul 14

PMID 22789112

Citations 22

Authors

Yi-Feng Wang

Hui Chen

Xu Zhu

Shunsuke Chiba

Affiliations

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Abstract

A method for the oxygenation of tertiary C-H bonds of N-alkylamidines and N-(2-alkylaryl)amidines is described that utilizes the CuBr·SMe(2)/2,2'-bipyridine catalytic system under an O(2) atmosphere and provides dihydrooxazoles and 4H-1,3-benzoxazines. The oxygen atom is incorporated from atmospheric molecular oxygen during the present process.

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