Role of Parasympathetic Nerves and Muscarinic Receptors in Allergy and Asthma

Overview

Journal Chem Immunol Allergy

Publisher Karger

Specialty Allergy & Immunology

Date 2012 Jul 7

PMID 22767057

Citations 19

Authors

Gregory D Scott

Allison D Fryer

Affiliations

Soon will be listed here.

Abstract

Parasympathetic nerves control the symptoms and inflammation of allergic diseases primarily by signaling through peripheral muscarinic receptors. Parasympathetic signaling targets classic effector tissues such as airway smooth muscle and secretory glands and mediates acute symptoms of allergic disease such as airway narrowing and increased mucus secretion. In addition, parasympathetic signaling modulates inflammatory cells and non-neuronal resident cell types such as fibroblasts and smooth muscle contributing to chronic allergic inflammation and tissue remodeling. Importantly, muscarinic antagonists are experiencing a rebirth for the treatment of asthma and may be useful for treating other allergic diseases.

Citing Articles

Recent advances in bronchial thermoplasty for severe asthma: a narrative review.

Wu S, Li S, Zhang P, Fang N, Qiu C Ann Transl Med. 2022; 10(6):370.

PMID: 35434008 PMC: 9011210. DOI: 10.21037/atm-22-580.

Association Between Asthma and Migraine: A Systematic Review and Meta-Analysis of Observational Studies.

Kang L, Chen P, Tung T, Chien C Front Allergy. 2022; 2:741135.

PMID: 35386963 PMC: 8974722. DOI: 10.3389/falgy.2021.741135.

My Life in HRV Biofeedback Research.

Lehrer P Appl Psychophysiol Biofeedback. 2022; 47(4):289-298.

PMID: 35254592 PMC: 8899772. DOI: 10.1007/s10484-022-09535-5.

Global transcriptome profile of the developmental principles of in vitro iPSC-to-motor neuron differentiation.

Solomon E, Davis-Anderson K, Hovde B, Micheva-Viteva S, Harris J, Twary S BMC Mol Cell Biol. 2021; 22(1):13.

PMID: 33602141 PMC: 7893891. DOI: 10.1186/s12860-021-00343-z.

Drug class effects on respiratory mechanics in animal models: access and applications.

Oliveira M, Lino-Alvarado A, Moriya H, Vitorasso R Exp Biol Med (Maywood). 2021; 246(9):1094-1103.

PMID: 33601911 PMC: 8113734. DOI: 10.1177/1535370221993095.

References

Izumi H . Reflex parasympathetic vasodilatation in facial skin. Gen Pharmacol. 1995; 26(2):237-44. DOI: 10.1016/0306-3623(94)00155-g. View

Sacchetti M, Micera A, Lambiase A, Speranza S, Mantelli F, Petrachi G . Tear levels of neuropeptides increase after specific allergen challenge in allergic conjunctivitis. Mol Vis. 2011; 17:47-52. PMC: 3021574. View

Klein M, Haberberger R, Hartmann P, Faulhammer P, Lips K, Krain B . Muscarinic receptor subtypes in cilia-driven transport and airway epithelial development. Eur Respir J. 2009; 33(5):1113-21. PMC: 3895332. DOI: 10.1183/09031936.00015108. View

Peters S, Kunselman S, Icitovic N, Moore W, Pascual R, Ameredes B . Tiotropium bromide step-up therapy for adults with uncontrolled asthma. N Engl J Med. 2010; 363(18):1715-26. PMC: 3011177. DOI: 10.1056/NEJMoa1008770. View

Sahin-Yilmaz A, Nocon C, Corey J . Immunoglobulin E-mediated food allergies among adults with allergic rhinitis. Otolaryngol Head Neck Surg. 2010; 143(3):379-85. DOI: 10.1016/j.otohns.2010.04.271. View

Caulfield M, Birdsall N . International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev. 1998; 50(2):279-90. View

Blanchet M, Israel-Assayag E, Cormier Y . Modulation of airway inflammation and resistance in mice by a nicotinic receptor agonist. Eur Respir J. 2005; 26(1):21-7. DOI: 10.1183/09031936.05.00116104. View

Belvisi M, Stretton C, Yacoub M, Barnes P . Nitric oxide is the endogenous neurotransmitter of bronchodilator nerves in humans. Eur J Pharmacol. 1992; 210(2):221-2. DOI: 10.1016/0014-2999(92)90676-u. View

Tobin M, Moparty B, Farhadi A, DeMeo M, Bansal P, Keshavarzian A . Atopic irritable bowel syndrome: a novel subgroup of irritable bowel syndrome with allergic manifestations. Ann Allergy Asthma Immunol. 2008; 100(1):49-53. DOI: 10.1016/S1081-1206(10)60404-8. View

10.

Frisby C, Fraser R, Schirmer M, Yeoh E, Blackshaw L . Roles of muscarinic receptor subtypes in small intestinal motor dysfunction in acute radiation enteritis. Am J Physiol Gastrointest Liver Physiol. 2007; 293(1):G121-7. DOI: 10.1152/ajpgi.00469.2006. View

11.

Blanquet F, Abysique A, Gonella J . In vivo study of the role of muscarinic receptors in the parasympathetic control of rabbit colonic motility. J Auton Nerv Syst. 1994; 46(3):217-27. DOI: 10.1016/0165-1838(94)90039-6. View

12.

Kubo N, Minami T, Hori Y, Yamashita T, Kumazawa T . Enhanced parasympathetic nerve activities in experimentally-induced nasal hypersensitivity. Acta Otolaryngol Suppl. 1989; 463:14-20. DOI: 10.3109/00016488909138628. View

13.

Chiba Y, Misawa M . Characteristics of muscarinic cholinoceptors in airways of antigen-induced airway hyperresponsive rats. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. 1995; 111(3):351-7. DOI: 10.1016/0742-8413(95)00061-5. View

14.

Dartt D, McCarthy D, Mercer H, Kessler T, Chung E, Zieske J . Localization of nerves adjacent to goblet cells in rat conjunctiva. Curr Eye Res. 1995; 14(11):993-1000. DOI: 10.3109/02713689508998520. View

15.

White M . Muscarinic receptors in human airways. J Allergy Clin Immunol. 1995; 95(5 Pt 2):1065-8. DOI: 10.1016/s0091-6749(95)70209-1. View

16.

Fryer A, El-Fakahany E, Jacoby D . Parainfluenza virus type 1 reduces the affinity of agonists for muscarinic receptors in guinea-pig lung and heart. Eur J Pharmacol. 1990; 181(1-2):51-8. DOI: 10.1016/0014-2999(90)90244-z. View

17.

Fantini F, Pincelli C, Romualdi P, Donatini A, Giannetti A . Substance P levels are decreased in lesional skin of atopic dermatitis. Exp Dermatol. 1992; 1(3):127-8. DOI: 10.1111/j.1600-0625.1992.tb00003.x. View

18.

Kaji A, Shigematsu H, Fujita K, Maeda T, Watanabe S . Parasympathetic innervation of cutaneous blood vessels by vasoactive intestinal polypeptide-immunoreactive and acetylcholinesterase-positive nerves: histochemical and experimental study on rat lower lip. Neuroscience. 1988; 25(1):353-62. DOI: 10.1016/0306-4522(88)90031-0. View

19.

Yost B, Gleich G, Fryer A . Ozone-induced hyperresponsiveness and blockade of M2 muscarinic receptors by eosinophil major basic protein. J Appl Physiol (1985). 1999; 87(4):1272-8. DOI: 10.1152/jappl.1999.87.4.1272. View

20.

Birchall M, HENDERSON J, Pride N, Fuller R . A comparison of the effects of an alpha-agonist, an anti-muscarinic agent and placebo on intranasal histamine challenge in allergic rhinitis. Clin Otolaryngol Allied Sci. 1996; 21(3):212-7. DOI: 10.1111/j.1365-2273.1996.tb01727.x. View