Development and Homeostasis of the Skin Epidermis

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2012 Jul 4

PMID 22751151

Citations 46

Authors

Panagiota A Sotiropoulou

Cedric Blanpain

Affiliations

Soon will be listed here.

Abstract

The skin epidermis is a stratified epithelium that forms a barrier that protects animals from dehydration, mechanical stress, and infections. The epidermis encompasses different appendages, such as the hair follicle (HF), the sebaceous gland (SG), the sweat gland, and the touch dome, that are essential for thermoregulation, sensing the environment, and influencing social behavior. The epidermis undergoes a constant turnover and distinct stem cells (SCs) are responsible for the homeostasis of the different epidermal compartments. Deregulation of the signaling pathways controlling the balance between renewal and differentiation often leads to cancer formation.

Citing Articles

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Genetic and histological relationship between pheromone-secreting tissues of the musk gland and skin of juvenile Chinese forest musk deer ( Flerov, 1929).

Li L, Cao H, Yang J, Jin T, Ma Y, Wang Y J Zhejiang Univ Sci B. 2023; 24(9):807-822.

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