Article: Sikokianin D, a new C-3/C-3"-biflavanone from the roots of Wikstroemia indica

A new 3,3''-biflavanone, sikokianin D (1), was isolated from the roots of Wikstroemia indica, together with two known compounds. Their structures were elucidated by chemical evidence and spectral analyses, including HR-ESI-MS, and 1D- and 2D-NMR techniques.

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References

1.

Yueqin Z, Recio M, Manez S, Giner R, Cerda-Nicolas M, Rios J . Isolation of two triterpenoids and a biflavanone with anti-Inflammatory activity from Schinus molle fruits. Planta Med. 2003; 69(10):893-8. DOI: 10.1055/s-2003-45096. View

2.

Liu W, Cheung F, Liu B, Li C, Ye W, Che C . Involvement of p21 and FasL in induction of cell cycle arrest and apoptosis by neochamaejasmin A in human prostate LNCaP cancer cells. J Nat Prod. 2008; 71(5):842-6. DOI: 10.1021/np8001223. View

3.

Huang W, Zhang X, Wang Y, Ye W, Ooi V, Chung H . Antiviral biflavonoids from Radix Wikstroemiae (Liaogewanggen). Chin Med. 2010; 5:23. PMC: 2907371. DOI: 10.1186/1749-8546-5-23. View

4.

Lee K, TAGAHARA K, Suzuki H, Wu R, Haruna M, Hall I . Antitumor agents. 49 tricin, kaempferol-3-O-beta-D-glucopyranoside and (+)-nortrachelogenin, antileukemic principles from Wikstroemia indica. J Nat Prod. 1981; 44(5):530-5. DOI: 10.1021/np50017a003. View

5.

Nunome S, Ishiyama A, Kobayashi M, Otoguro K, Kiyohara H, Yamada H . In vitro antimalarial activity of biflavonoids from Wikstroemia indica. Planta Med. 2004; 70(1):76-8. DOI: 10.1055/s-2004-815462. View

6.

Ko F, Chang Y, Kuo Y, Lin Y, Teng C . Daphnoretin, a new protein kinase C activator isolated from Wikstroemia indica C.A. Mey. Biochem J. 1993; 295 ( Pt 1):321-7. PMC: 1134857. DOI: 10.1042/bj2950321. View

7.

Tian Q, Li J, Xie X, Sun M, Sang H, Zhou C . Stereospecific induction of nuclear factor-kappaB activation by isochamaejasmin. Mol Pharmacol. 2005; 68(6):1534-42. DOI: 10.1124/mol.105.014720. View

8.

Hu K, Kobayashi H, Dong A, Iwasaki S, Yao X . Antifungal, antimitotic and anti-HIV-1 agents from the roots of Wikstroemia indica. Planta Med. 2000; 66(6):564-7. DOI: 10.1055/s-2000-8601. View

9.

Wang L, Unehara T, Kitanaka S . Anti-inflammatory activity of new guaiane type sesquiterpene from Wikstroemia indica. Chem Pharm Bull (Tokyo). 2005; 53(1):137-9. DOI: 10.1248/cpb.53.137. View

10.

Ho W, Xue J, Sun S, Ooi V, Li Y . Antiviral activity of daphnoretin isolated from Wikstroemia indica. Phytother Res. 2009; 24(5):657-61. DOI: 10.1002/ptr.2935. View

11.

Li J, Zhao W, Hu J, Cao X, Yang J, Li X . A New C-3/C-3"-Biflavanone from the Roots of Stellera chamaejasme L. Molecules. 2014; 16(8):6465-9. PMC: 6264493. DOI: 10.3390/molecules16086465. View

Sikokianin D, a New C-3/C-3"-biflavanone from the Roots of Wikstroemia Indica