Mitochondrial Dynamics: the Intersection of Form and Function

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2012 Jun 26

PMID 22729853

Citations 41

Authors

Andrew Ferree

Orian Shirihai

Affiliations

Soon will be listed here.

Abstract

Mitochondria within a cell exist as a population in a dynamic -morphological continuum. The balance of mitochondrial fusion and fission dictates a spectrum of shapes from interconnected networks to fragmented individual units. This plasticity bestows the adaptive flexibility needed to adjust to changing cellular stresses and metabolic demands. The mechanisms that regulate mitochondrial dynamics, their importance in normal cell biology, and the roles they play in disease conditions are only beginning to be understood. Dysfunction of mitochondrial dynamics has been identified as a possible disease mechanism in Parkinson's disease. This chapter will introduce the budding field of mitochondrial dynamics and explore unique characteristics of affected neurons in Parkinson's disease that increase susceptibility to disruptions in mitochondrial dynamics.

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