Wnt Signaling and Injury Repair

Overview

Journal Cold Spring Harb Perspect Biol

Specialties Biology
Molecular Biology

Date 2012 Jun 23

PMID 22723493

Citations 120

Authors

Jemima L Whyte

Andrew A Smith

Jill A Helms

Affiliations

Soon will be listed here.

Abstract

Wnt signaling is activated by wounding and participates in every subsequent stage of the healing process from the control of inflammation and programmed cell death, to the mobilization of stem cell reservoirs within the wound site. In this review we summarize recent data elucidating the roles that the Wnt pathway plays in the injury repair process. These data provide a foundation for potential Wnt-based therapeutic strategies aimed at stimulating tissue regeneration.

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References

Vermeulen L, de Sousa E Melo F, van der Heijden M, Cameron K, de Jong J, Borovski T . Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol. 2010; 12(5):468-76. DOI: 10.1038/ncb2048. View

Kersting M, Friedl C, Kraus A, Behn M, Pankow W, Schuermann M . Differential frequencies of p16(INK4a) promoter hypermethylation, p53 mutation, and K-ras mutation in exfoliative material mark the development of lung cancer in symptomatic chronic smokers. J Clin Oncol. 2000; 18(18):3221-9. DOI: 10.1200/JCO.2000.18.18.3221. View

Kim J, Kim J, Kim D, Ha Y, Ihm M, Kim H . Wnt5a induces endothelial inflammation via beta-catenin-independent signaling. J Immunol. 2010; 185(2):1274-82. DOI: 10.4049/jimmunol.1000181. View

Petersen C, Reddien P . A wound-induced Wnt expression program controls planarian regeneration polarity. Proc Natl Acad Sci U S A. 2009; 106(40):17061-6. PMC: 2743725. DOI: 10.1073/pnas.0906823106. View

Kubo F, Takeichi M, Nakagawa S . Wnt2b controls retinal cell differentiation at the ciliary marginal zone. Development. 2002; 130(3):587-98. DOI: 10.1242/dev.00244. View

Choi Y, Arron J, Townsend M . Promising bone-related therapeutic targets for rheumatoid arthritis. Nat Rev Rheumatol. 2009; 5(10):543-8. PMC: 2797318. DOI: 10.1038/nrrheum.2009.175. View

Raymond P, Barthel L, Bernardos R, Perkowski J . Molecular characterization of retinal stem cells and their niches in adult zebrafish. BMC Dev Biol. 2006; 6:36. PMC: 1564002. DOI: 10.1186/1471-213X-6-36. View

Morrell N, Leucht P, Zhao L, Kim J, Ten Berge D, Ponnusamy K . Liposomal packaging generates Wnt protein with in vivo biological activity. PLoS One. 2008; 3(8):e2930. PMC: 2515347. DOI: 10.1371/journal.pone.0002930. View

Mazumdar J, OBrien W, Johnson R, LaManna J, Chavez J, Klein P . O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol. 2010; 12(10):1007-13. PMC: 3144143. DOI: 10.1038/ncb2102. View

10.

Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B . The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med. 2003; 349(26):2483-94. DOI: 10.1056/NEJMoa030847. View

11.

Rubinfeld B, Robbins P, Albert I, Porfiri E, Polakis P . Stabilization of beta-catenin by genetic defects in melanoma cell lines. Science. 1997; 275(5307):1790-2. DOI: 10.1126/science.275.5307.1790. View

12.

Qyang Y, Martin-Puig S, Chiravuri M, Chen S, Xu H, Bu L . The renewal and differentiation of Isl1+ cardiovascular progenitors are controlled by a Wnt/beta-catenin pathway. Cell Stem Cell. 2008; 1(2):165-79. DOI: 10.1016/j.stem.2007.05.018. View

13.

Kragl M, Knapp D, Nacu E, Khattak S, Maden M, Epperlein H . Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature. 2009; 460(7251):60-5. DOI: 10.1038/nature08152. View

14.

Zhao J, Kim K, De Vera J, Palencia S, Wagle M, Abo A . R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/beta-catenin pathway. Proc Natl Acad Sci U S A. 2009; 106(7):2331-6. PMC: 2650156. DOI: 10.1073/pnas.0805159106. View

15.

Clevers H . Wnt/beta-catenin signaling in development and disease. Cell. 2006; 127(3):469-80. DOI: 10.1016/j.cell.2006.10.018. View

16.

Cameron D, Vafai H, White J . Analysis of dendritic arbors of native and regenerated ganglion cells in the goldfish retina. Vis Neurosci. 1999; 16(2):253-61. DOI: 10.1017/s0952523899162060. View

17.

Larson B, Longaker M, Lorenz H . Scarless fetal wound healing: a basic science review. Plast Reconstr Surg. 2010; 126(4):1172-1180. PMC: 4229131. DOI: 10.1097/PRS.0b013e3181eae781. View

18.

Kim J, Leucht P, Lam K, Luppen C, Ten Berge D, Nusse R . Bone regeneration is regulated by wnt signaling. J Bone Miner Res. 2007; 22(12):1913-23. DOI: 10.1359/jbmr.070802. View

19.

Popelut A, Rooker S, Leucht P, Medio M, Brunski J, Helms J . The acceleration of implant osseointegration by liposomal Wnt3a. Biomaterials. 2010; 31(35):9173-81. DOI: 10.1016/j.biomaterials.2010.08.045. View

20.

Mescher A, Neff A . Regenerative capacity and the developing immune system. Adv Biochem Eng Biotechnol. 2005; 93:39-66. DOI: 10.1007/b99966. View