Hospitalization Due to Human Parainfluenza Virus-associated Lower Respiratory Tract Illness in Rural Thailand

Overview

Journal Influenza Other Respir Viruses

Publisher Wiley

Specialty Microbiology

Date 2012 Jun 22

PMID 22716273

Citations 11

Authors

Oliver W Morgan

Malinee Chittaganpitch

Birgit Clague

Somrak Chantra

Wichai Sanasuttipun

Prabda Prapasiri

Sathapana Naorat

Yongjua Laosirithavorn

Teresa C T Peret

Dean D Erdman

Henry C Baggett

Sonja J Olsen

Alicia M Fry

Affiliations

Soon will be listed here.

Abstract

Background: Human parainfluenza viruses (HPIVs) are an important cause of acute respiratory illness in young children but little is known about their epidemiology in the tropics.

Methods: From 2003-2007, we conducted surveillance for hospitalized respiratory illness in rural Thailand. We performed reverse-transcriptase polymerase chain reaction on nasopharyngeal specimens and enzyme immunoassay on paired sera.

Results: Of 10,097 patients enrolled, 573 (5%) of all ages and 370 (9%) of children <5 years of age had evidence of HPIV infection (HPIV1=189, HPIV2=54, HPIV3=305, untyped=27). Average adjusted annual incidence of HPIV-associated hospitalized respiratory illness was greatest in children aged <1 year (485 per 100,000 person years).

Conclusions: In Thailand, HPIV caused substantial illnesses requiring hospitalization in young children.

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References

Fry A, Lu X, Chittaganpitch M, Peret T, Fischer J, Dowell S . Human bocavirus: a novel parvovirus epidemiologically associated with pneumonia requiring hospitalization in Thailand. J Infect Dis. 2007; 195(7):1038-45. PMC: 7109861. DOI: 10.1086/512163. View

Fry A, Chittaganpitch M, Baggett H, Peret T, Dare R, Sawatwong P . The burden of hospitalized lower respiratory tract infection due to respiratory syncytial virus in rural Thailand. PLoS One. 2010; 5(11):e15098. PMC: 2994907. DOI: 10.1371/journal.pone.0015098. View

Chew F, Doraisingham S, Ling A, Kumarasinghe G, Lee B . Seasonal trends of viral respiratory tract infections in the tropics. Epidemiol Infect. 1998; 121(1):121-8. PMC: 2809482. DOI: 10.1017/s0950268898008905. View

Dare R, Fry A, Chittaganpitch M, Sawanpanyalert P, Olsen S, Erdman D . Human coronavirus infections in rural Thailand: a comprehensive study using real-time reverse-transcription polymerase chain reaction assays. J Infect Dis. 2007; 196(9):1321-8. PMC: 7109921. DOI: 10.1086/521308. View

Erdman D, Weinberg G, Edwards K, Walker F, Anderson B, Winter J . GeneScan reverse transcription-PCR assay for detection of six common respiratory viruses in young children hospitalized with acute respiratory illness. J Clin Microbiol. 2003; 41(9):4298-303. PMC: 193844. DOI: 10.1128/JCM.41.9.4298-4303.2003. View

Marx A, Gary Jr H, Marston B, Erdman D, Breiman R, Torok T . Parainfluenza virus infection among adults hospitalized for lower respiratory tract infection. Clin Infect Dis. 1999; 29(1):134-40. DOI: 10.1086/520142. View

Weinberg G, Erdman D, Edwards K, Hall C, Walker F, Griffin M . Superiority of reverse-transcription polymerase chain reaction to conventional viral culture in the diagnosis of acute respiratory tract infections in children. J Infect Dis. 2004; 189(4):706-10. DOI: 10.1086/381456. View

Simmerman J, Lertiendumrong J, Dowell S, Uyeki T, Olsen S, Chittaganpitch M . The cost of influenza in Thailand. Vaccine. 2006; 24(20):4417-26. DOI: 10.1016/j.vaccine.2005.12.060. View

Phares C, Wangroongsarb P, Chantra S, Paveenkitiporn W, Tondella M, Benson R . Epidemiology of severe pneumonia caused by Legionella longbeachae, Mycoplasma pneumoniae, and Chlamydia pneumoniae: 1-year, population-based surveillance for severe pneumonia in Thailand. Clin Infect Dis. 2008; 45(12):e147-55. DOI: 10.1086/523003. View

10.

Moscona A, Porotto M, Palmer S, Tai C, Aschenbrenner L, Triana-Baltzer G . A recombinant sialidase fusion protein effectively inhibits human parainfluenza viral infection in vitro and in vivo. J Infect Dis. 2010; 202(2):234-41. PMC: 2891144. DOI: 10.1086/653621. View

11.

Glezen P, Denny F . Epidemiology of acute lower respiratory disease in children. N Engl J Med. 1973; 288(10):498-505. DOI: 10.1056/NEJM197303082881005. View

12.

Fry A, Curns A, Harbour K, Hutwagner L, Holman R, Anderson L . Seasonal trends of human parainfluenza viral infections: United States, 1990-2004. Clin Infect Dis. 2006; 43(8):1016-22. DOI: 10.1086/507638. View

13.

Henrickson K . Parainfluenza viruses. Clin Microbiol Rev. 2003; 16(2):242-64. PMC: 153148. DOI: 10.1128/CMR.16.2.242-264.2003. View

14.

Karron R, Belshe R, Wright P, Thumar B, Burns B, Newman F . A live human parainfluenza type 3 virus vaccine is attenuated and immunogenic in young infants. Pediatr Infect Dis J. 2003; 22(5):394-405. DOI: 10.1097/01.inf.0000066244.31769.83. View

15.

Olsen S, Thamthitiwat S, Chantra S, Chittaganpitch M, Fry A, Simmerman J . Incidence of respiratory pathogens in persons hospitalized with pneumonia in two provinces in Thailand. Epidemiol Infect. 2010; 138(12):1811-22. DOI: 10.1017/S0950268810000646. View

16.

Weinberg G, Hall C, Iwane M, Poehling K, Edwards K, Griffin M . Parainfluenza virus infection of young children: estimates of the population-based burden of hospitalization. J Pediatr. 2009; 154(5):694-9. DOI: 10.1016/j.jpeds.2008.11.034. View

17.

Hall C . Respiratory syncytial virus and parainfluenza virus. N Engl J Med. 2001; 344(25):1917-28. DOI: 10.1056/NEJM200106213442507. View

18.

Marx A, Torok T, Holman R, Clarke M, Anderson L . Pediatric hospitalizations for croup (laryngotracheobronchitis): biennial increases associated with human parainfluenza virus 1 epidemics. J Infect Dis. 1997; 176(6):1423-7. DOI: 10.1086/514137. View

19.

Simmerman J, Chittaganpitch M, Levy J, Chantra S, Maloney S, Uyeki T . Incidence, seasonality and mortality associated with influenza pneumonia in Thailand: 2005-2008. PLoS One. 2009; 4(11):e7776. PMC: 2777392. DOI: 10.1371/journal.pone.0007776. View

20.

Suwanjutha S, Chantarojanasiri T, Sirinavin S, Ruangkanchanasetr S, Hotrakitya S, Wasi C . A study of nonbacterial agents of acute lower respiratory tract infection in Thai children. Rev Infect Dis. 1990; 12 Suppl 8:S923-8. DOI: 10.1093/clinids/12.supplement_8.s923. View