Cannabinoid-like Anti-inflammatory Compounds from Flax Fiber

Overview

Journal Cell Mol Biol Lett

Publisher Biomed Central

Specialties Biochemistry
Cell Biology
Molecular Biology

Date 2012 Jun 19

PMID 22706678

Citations 12

Authors

Monika Styrczewska

Anna Kulma

Katarzyna Ratajczak

Ryszard Amarowicz

Jan Szopa

Affiliations

Soon will be listed here.

Abstract

Flax is a valuable source of fibers, linseed and oil. The compounds of the latter two products have already been widely examined and have been proven to possess many health-beneficial properties. In the course of analysis of fibers extract from previously generated transgenic plants overproducing phenylpropanoids a new terpenoid compound was discovered.The UV spectra and the retention time in UPLC analysis of this new compound reveal similarity to a cannabinoid-like compound, probably cannabidiol (CBD). This was confirmed by finding two ions at m/z 174.1 and 231.2 in mass spectra analysis. Further confirmation of the nature of the compound was based on a biological activity assay. It was found that the compound affects the expression of genes involved in inflammatory processes in mouse and human fibroblasts and likely the CBD from Cannabis sativa activates the specific peripheral cannabinoid receptor 2 (CB2) gene expression. Besides fibers, the compound was also found in all other flax tissues. It should be pointed out that the industrial process of fabric production does not affect CBD activity.The presented data suggest for the first time that flax products can be a source of biologically active cannabinoid-like compounds that are able to influence the cell immunological response. These findings might open up many new applications for medical flax products, especially for the fabric as a material for wound dressing with anti-inflammatory properties.

Citing Articles

Cannabidiol: potential in treatment of neurological diseases, flax as a possible natural source of cannabidiol.

Storozhuk M Front Cell Neurosci. 2023; 17:1131653.

PMID: 37138768 PMC: 10150377. DOI: 10.3389/fncel.2023.1131653.

Mass Spectrometry-Based Metabolomics of Phytocannabinoids from Non-Cannabis Plant Origins.

Sommano S, Sunanta P, Leksawasdi N, Jantanasakulwong K, Rachtanapun P, Seesuriyachan P Molecules. 2022; 27(10).

PMID: 35630777 PMC: 9147514. DOI: 10.3390/molecules27103301.

Wound coverage by the linen dressing accelerates ulcer healing.

Skorkowska-Telichowska K, Mierziak-Darecka J, Wrobel-Kwiatkowska M, Gebarowski T, Szopa J, Zuk M Postepy Dermatol Alergol. 2021; 38(5):827-841.

PMID: 34849131 PMC: 8610069. DOI: 10.5114/ada.2021.110116.

Quality of Life and a Surveillant Endocannabinoid System.

de Melo Reis R, Isaac A, Freitas H, Almeida M, Schuck P, Ferreira G Front Neurosci. 2021; 15:747229.

PMID: 34776851 PMC: 8581450. DOI: 10.3389/fnins.2021.747229.

Hydration and Sorption Properties of Raw and Milled Flax Fibers.

Karoyo A, Dehabadi L, Alabi W, Simonson C, Wilson L ACS Omega. 2020; 5(11):6113-6121.

PMID: 32226894 PMC: 7098004. DOI: 10.1021/acsomega.0c00100.

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