Mass Spectrometry-Based Metabolomics of Phytocannabinoids from Non-Cannabis Plant Origins

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2022 May 28

PMID 35630777

Authors

Sarana Rose Sommano

Piyachat Sunanta

Noppol Leksawasdi

Kittisak Jantanasakulwong

Pornchai Rachtanapun

Phisit Seesuriyachan

Yuthana Phimolsiripol

Korawan Sringarm

Warintorn Ruksiriwanich

Pensak Jantrawut

Chuda Chittasupho

Affiliations

Soon will be listed here.

Abstract

Phytocannabinoids are isoprenylated resorcinyl polyketides produced mostly in glandular trichomes of L. These discoveries led to the identification of cannabinoid receptors, which modulate psychotropic and pharmacological reactions and are found primarily in the human central nervous system. As a result of the biogenetic process, aliphatic ketide phytocannabinoids are exclusively found in the cannabis species and have a limited natural distribution, whereas phenethyl-type phytocannabinoids are present in higher plants, liverworts, and fungi. The development of cannabinomics has uncovered evidence of new sources containing various phytocannabinoid derivatives. Phytocannabinoids have been isolated as artifacts from their carboxylated forms (pre-cannabinoids or acidic cannabinoids) from plant sources. In this review, the overview of the phytocannabinoid biosynthesis is presented. Different non-cannabis plant sources are described either from those belonging to the angiosperm species and bryophytes, together with their metabolomic structures. Lastly, we discuss the legal framework for the ingestion of these biological materials which currently receive the attention as a legal high.

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